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The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. Vicuña L, et al. Among authors: kuner r. Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27. Nat Med. 2015. PMID: 25915831 Free PMC article.
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Agarwal N, et al. Among authors: kuner r. Nat Neurosci. 2007 Jul;10(7):870-9. doi: 10.1038/nn1916. Epub 2007 Jun 10. Nat Neurosci. 2007. PMID: 17558404 Free PMC article.
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.
Bishay P, Schmidt H, Marian C, Häussler A, Wijnvoord N, Ziebell S, Metzner J, Koch M, Myrczek T, Bechmann I, Kuner R, Costigan M, Dehghani F, Geisslinger G, Tegeder I. Bishay P, et al. Among authors: kuner r. PLoS One. 2010 May 13;5(5):e10628. doi: 10.1371/journal.pone.0010628. PLoS One. 2010. PMID: 20498712 Free PMC article.
Central mechanisms of pathological pain.
Kuner R. Kuner R. Nat Med. 2010 Nov;16(11):1258-66. doi: 10.1038/nm.2231. Epub 2010 Oct 14. Nat Med. 2010. PMID: 20948531 Review.
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Gangadharan V, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali KK, Agarwal N, Tegeder I, Hildebrandt U, Nagy GG, Todd AJ, Ghirri A, Häussler A, Sprengel R, Seeburg PH, MacDermott AB, Lewin GR, Kuner R. Gangadharan V, et al. Among authors: kuner r. J Clin Invest. 2011 Apr;121(4):1608-23. doi: 10.1172/JCI44911. Epub 2011 Mar 7. J Clin Invest. 2011. PMID: 21383497 Free PMC article.
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R. Luo C, et al. Among authors: kuner t, kuner r. PLoS Biol. 2012;10(3):e1001283. doi: 10.1371/journal.pbio.1001283. Epub 2012 Mar 13. PLoS Biol. 2012. PMID: 22427743 Free PMC article.
A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo.
Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Škoricová D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R. Gangadharan V, et al. Among authors: kuner t, kuner r. Pain. 2013 Dec;154(12):2801-2812. doi: 10.1016/j.pain.2013.08.019. Epub 2013 Aug 22. Pain. 2013. PMID: 23973358
199 results