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Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif.
Taniguchi M, Fujiwara K, Nakai Y, Ozaki T, Koshikawa N, Toshio K, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma M, Nagase H. Taniguchi M, et al. Among authors: fujiwara k. FEBS Open Bio. 2014 Mar 13;4:328-34. doi: 10.1016/j.fob.2014.03.004. eCollection 2014. FEBS Open Bio. 2014. PMID: 24918046 Free PMC article.
Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.
Obinata D, Ito A, Fujiwara K, Takayama K, Ashikari D, Murata Y, Yamaguchi K, Urano T, Fujimura T, Fukuda N, Soma M, Watanabe T, Nagase H, Inoue S, Takahashi S. Obinata D, et al. Among authors: fujiwara k. Cancer Sci. 2014 Oct;105(10):1272-8. doi: 10.1111/cas.12493. Epub 2014 Sep 18. Cancer Sci. 2014. PMID: 25088707 Free PMC article.
Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation.
Mishra R, Watanabe T, Kimura MT, Koshikawa N, Ikeda M, Uekusa S, Kawashima H, Wang X, Igarashi J, Choudhury D, Grandori C, Kemp CJ, Ohira M, Verma NK, Kobayashi Y, Takeuchi J, Koshinaga T, Nemoto N, Fukuda N, Soma M, Kusafuka T, Fujiwara K, Nagase H. Mishra R, et al. Among authors: fujiwara k. Cancer Sci. 2015 Apr;106(4):421-9. doi: 10.1111/cas.12610. Epub 2015 Mar 3. Cancer Sci. 2015. PMID: 25611295 Free PMC article.
Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
Igarashi J, Fukuda N, Inoue T, Nakai S, Saito K, Fujiwara K, Matsuda H, Ueno T, Matsumoto Y, Watanabe T, Nagase H, Bando T, Sugiyama H, Itoh T, Soma M. Igarashi J, et al. Among authors: fujiwara k. PLoS One. 2015 May 4;10(5):e0125295. doi: 10.1371/journal.pone.0125295. eCollection 2015. PLoS One. 2015. PMID: 25938472 Free PMC article.
Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.
Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O, Nagase H, Ozaki T. Sugimoto H, et al. Among authors: fujiwara k. Cell Death Dis. 2015 Oct 15;6(10):e1914. doi: 10.1038/cddis.2015.242. Cell Death Dis. 2015. PMID: 26469963 Free PMC article. No abstract available.
3,532 results