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Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.
Dowsett L, Piper S, Slaviero A, Dufton N, Wang Z, Boruc O, Delahaye M, Colman L, Kalk E, Tomlinson J, Birdsey G, Randi AM, Leiper J. Dowsett L, et al. Among authors: leiper j. Circulation. 2015 Jun 23;131(25):2217-25. doi: 10.1161/CIRCULATIONAHA.114.015064. Epub 2015 Apr 24. Circulation. 2015. PMID: 25910799
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase.
Leiper J, Murray-Rust J, McDonald N, Vallance P. Leiper J, et al. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13527-32. doi: 10.1073/pnas.212269799. Epub 2002 Oct 7. Proc Natl Acad Sci U S A. 2002. PMID: 12370443 Free PMC article.
We recently solved the crystal structure of a bacterial DDAH and identified a Cys-His-Glu catalytic triad [Murray-Rust, J., Leiper, J. M., McAlister, M., Phelan, J., Tilley, S., Santa Maria, J., Vallance, P. & McDonald, N. (2001) Nat. ...
We recently solved the crystal structure of a bacterial DDAH and identified a Cys-His-Glu catalytic triad [Murray-Rust, J., Leiper …
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, Vallance P. Achan V, et al. Among authors: leiper j. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1455-9. doi: 10.1161/01.ATV.0000081742.92006.59. Epub 2003 Jun 12. Arterioscler Thromb Vasc Biol. 2003. PMID: 12805079 Clinical Trial.
Peroxisomes proliferate.
Leiper JM, Birdsey GM, Oatey PB. Leiper JM, et al. Trends Cell Biol. 1995 Nov;5(11):435-7. doi: 10.1016/s0962-8924(00)89103-5. Trends Cell Biol. 1995. PMID: 14732049 No abstract available.
184 results