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Page 1
Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.
Dowsett L, Piper S, Slaviero A, Dufton N, Wang Z, Boruc O, Delahaye M, Colman L, Kalk E, Tomlinson J, Birdsey G, Randi AM, Leiper J. Dowsett L, et al. Among authors: boruc o. Circulation. 2015 Jun 23;131(25):2217-25. doi: 10.1161/CIRCULATIONAHA.114.015064. Epub 2015 Apr 24. Circulation. 2015. PMID: 25910799
Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis.
Lambden S, Kelly P, Ahmetaj-Shala B, Wang Z, Lee B, Nandi M, Torondel B, Delahaye M, Dowsett L, Piper S, Tomlinson J, Caplin B, Colman L, Boruc O, Slaviero A, Zhao L, Oliver E, Khadayate S, Singer M, Arrigoni F, Leiper J. Lambden S, et al. Among authors: boruc o. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1382-92. doi: 10.1161/ATVBAHA.115.305278. Epub 2015 Apr 9. Arterioscler Thromb Vasc Biol. 2015. PMID: 25857313
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
Lambden S, Martin D, Vanezis K, Lee B, Tomlinson J, Piper S, Boruc O, Mythen M, Leiper J. Lambden S, et al. Among authors: boruc o. Nitric Oxide. 2016 Aug 31;58:59-66. doi: 10.1016/j.niox.2016.06.003. Epub 2016 Jun 16. Nitric Oxide. 2016. PMID: 27319282 Free article.
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.
Tomlinson JA, Caplin B, Boruc O, Bruce-Cobbold C, Cutillas P, Dormann D, Faull P, Grossman RC, Khadayate S, Mas VR, Nitsch DD, Wang Z, Norman JT, Wilcox CS, Wheeler DC, Leiper J. Tomlinson JA, et al. Among authors: boruc o. J Am Soc Nephrol. 2015 Dec;26(12):3045-59. doi: 10.1681/ASN.2014030280. Epub 2015 Apr 8. J Am Soc Nephrol. 2015. PMID: 25855779 Free PMC article.
Paternal microbiome perturbations impact offspring fitness.
Argaw-Denboba A, Schmidt TSB, Di Giacomo M, Ranjan B, Devendran S, Mastrorilli E, Lloyd CT, Pugliese D, Paribeni V, Dabin J, Pisaniello A, Espinola S, Crevenna A, Ghosh S, Humphreys N, Boruc O, Sarkies P, Zimmermann M, Bork P, Hackett JA. Argaw-Denboba A, et al. Among authors: boruc o. Nature. 2024 May;629(8012):652-659. doi: 10.1038/s41586-024-07336-w. Epub 2024 May 1. Nature. 2024. PMID: 38693261 Free PMC article.