Lavoie H - Search Results

1

Regulation of RAF protein kinases in ERK signalling.

Lavoie H, Therrien M. Lavoie H, et al. Nat Rev Mol Cell Biol. 2015 May;16(5):281-98. doi: 10.1038/nrm3979. Nat Rev Mol Cell Biol. 2015. PMID: 25907612 Review.

2

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.

Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M. Lavoie H, et al. Nat Chem Biol. 2013 Jul;9(7):428-36. doi: 10.1038/nchembio.1257. Epub 2013 May 19. Nat Chem Biol. 2013. PMID: 23685672 Free PMC article.

3

Dimerization-induced allostery in protein kinase regulation.

Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F. Lavoie H, et al. Trends Biochem Sci. 2014 Oct;39(10):475-86. doi: 10.1016/j.tibs.2014.08.004. Epub 2014 Sep 11. Trends Biochem Sci. 2014. PMID: 25220378 Review.

4

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M. Thevakumaran N, et al. Among authors: lavoie h. Nat Struct Mol Biol. 2015 Jan;22(1):37-43. doi: 10.1038/nsmb.2924. Epub 2014 Dec 1. Nat Struct Mol Biol. 2015. PMID: 25437913

5

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.

Kubiniok P, Lavoie H, Therrien M, Thibault P. Kubiniok P, et al. Among authors: lavoie h. Mol Cell Proteomics. 2017 Apr;16(4):663-679. doi: 10.1074/mcp.M116.065128. Epub 2017 Feb 10. Mol Cell Proteomics. 2017. PMID: 28188228 Free PMC article.

6

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien M. Jin T, et al. Among authors: lavoie h. Nat Commun. 2017 Oct 31;8(1):1211. doi: 10.1038/s41467-017-01274-0. Nat Commun. 2017. PMID: 29084939 Free PMC article.

7

MEK drives BRAF activation through allosteric control of KSR proteins.

Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M. Lavoie H, et al. Nature. 2018 Feb 22;554(7693):549-553. doi: 10.1038/nature25478. Epub 2018 Feb 12. Nature. 2018. PMID: 29433126 Free PMC article.

8

ERK signalling: a master regulator of cell behaviour, life and fate.

Lavoie H, Gagnon J, Therrien M. Lavoie H, et al. Nat Rev Mol Cell Biol. 2020 Oct;21(10):607-632. doi: 10.1038/s41580-020-0255-7. Epub 2020 Jun 23. Nat Rev Mol Cell Biol. 2020. PMID: 32576977 Review.

9

Functional characterization of a PROTAC directed against BRAF mutant V600E.

Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F. Posternak G, et al. Among authors: lavoie h. Nat Chem Biol. 2020 Nov;16(11):1170-1178. doi: 10.1038/s41589-020-0609-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778845 Free PMC article.

10

The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.

Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M. Ashton-Beaucage D, et al. Among authors: lavoie h. Cell. 2010 Oct 15;143(2):251-62. doi: 10.1016/j.cell.2010.09.014. Cell. 2010. PMID: 20946983 Free article.

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