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Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Dockendorff C, Faloon PW, Pu J, Yu M, Johnston S, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Dockendorff C, et al. Among authors: johnston s. Bioorg Med Chem Lett. 2015;25(10):2100-5. doi: 10.1016/j.bmcl.2015.03.073. Epub 2015 Apr 1. Bioorg Med Chem Lett. 2015. PMID: 25900219 Free PMC article.
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.
Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Youngsaye W, et al. Among authors: johnston s. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5502-5. doi: 10.1016/j.bmcl.2011.06.105. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21802942 Free PMC article.
Identification of small-molecule inhibitors of Trypansoma cruzi replication.
Germain AR, Carmody LC, Dockendorff C, Galan-Rodriguez C, Rodriguez A, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Schreiber SL, Munoz B. Germain AR, et al. Among authors: johnston s. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7197-200. doi: 10.1016/j.bmcl.2011.09.057. Epub 2011 Sep 29. Bioorg Med Chem Lett. 2011. PMID: 22018462
Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.
Nagiec MM, Duvall JR, Skepner AP, Howe EA, Bastien J, Comer E, Marie JC, Johnston SE, Negri J, Eichhorn M, Vantourout J, Clish C, Musunuru K, Foley M, Perez JR, Palmer MAJ. Nagiec MM, et al. Medchemcomm. 2018 Sep 14;9(11):1831-1842. doi: 10.1039/c8md00297e. eCollection 2018 Nov 1. Medchemcomm. 2018. PMID: 30542533 Free PMC article.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. Wellington S, et al. Among authors: johnston se. Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3. Nat Chem Biol. 2017. PMID: 28671682 Free PMC article.
Structural and conformational determinants of macrocycle cell permeability.
Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, Kihlberg J. Over B, et al. Nat Chem Biol. 2016 Dec;12(12):1065-1074. doi: 10.1038/nchembio.2203. Epub 2016 Oct 17. Nat Chem Biol. 2016. PMID: 27748751
The Drug Repurposing Hub: a next-generation drug library and information resource.
Corsello SM, Bittker JA, Liu Z, Gould J, McCarren P, Hirschman JE, Johnston SE, Vrcic A, Wong B, Khan M, Asiedu J, Narayan R, Mader CC, Subramanian A, Golub TR. Corsello SM, et al. Nat Med. 2017 Apr 7;23(4):405-408. doi: 10.1038/nm.4306. Nat Med. 2017. PMID: 28388612 Free PMC article. No abstract available.
Chasing Tails: Cathepsin-L Improves Structural Analysis of Histones by HX-MS.
Papanastasiou M, Mullahoo J, DeRuff KC, Bajrami B, Karageorgos I, Johnston SE, Peckner R, Myers SA, Carr SA, Jaffe JD. Papanastasiou M, et al. Mol Cell Proteomics. 2019 Oct;18(10):2089-2098. doi: 10.1074/mcp.RA119.001325. Epub 2019 Aug 13. Mol Cell Proteomics. 2019. PMID: 31409669 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33451480
3,407 results