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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Sidrauski C, et al. Among authors: fraser cs. Elife. 2015 Apr 15;4:e07314. doi: 10.7554/eLife.07314. Elife. 2015. PMID: 25875391 Free PMC article.
Toward a Kinetic Understanding of Eukaryotic Translation.
Sokabe M, Fraser CS. Sokabe M, et al. Among authors: fraser cs. Cold Spring Harb Perspect Biol. 2019 Feb 1;11(2):a032706. doi: 10.1101/cshperspect.a032706. Cold Spring Harb Perspect Biol. 2019. PMID: 29959192 Free PMC article. Review.
Structure of a human 48S translational initiation complex.
Brito Querido J, Sokabe M, Kraatz S, Gordiyenko Y, Skehel JM, Fraser CS, Ramakrishnan V. Brito Querido J, et al. Among authors: fraser cs. Science. 2020 Sep 4;369(6508):1220-1227. doi: 10.1126/science.aba4904. Science. 2020. PMID: 32883864 Free PMC article.
eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Lapointe CP, Grosely R, Sokabe M, Alvarado C, Wang J, Montabana E, Villa N, Shin BS, Dever TE, Fraser CS, Fernández IS, Puglisi JD. Lapointe CP, et al. Among authors: fraser cs. Nature. 2022 Jul;607(7917):185-190. doi: 10.1038/s41586-022-04858-z. Epub 2022 Jun 22. Nature. 2022. PMID: 35732735 Free PMC article.
65 results