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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG. Benjannet S, et al. Among authors: mayne j. J Biol Chem. 2004 Nov 19;279(47):48865-75. doi: 10.1074/jbc.M409699200. Epub 2004 Sep 9. J Biol Chem. 2004. PMID: 15358785 Free article.
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.
Mbikay M, Croissandeau G, Sirois F, Anini Y, Mayne J, Seidah NG, Chrétien M. Mbikay M, et al. Among authors: mayne j. Dev Biol. 2007 Jun 15;306(2):584-98. doi: 10.1016/j.ydbio.2007.03.523. Epub 2007 Apr 1. Dev Biol. 2007. PMID: 17490633 Free article.
Plasma PCSK9 levels correlate with cholesterol in men but not in women.
Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC. Mayne J, et al. Biochem Biophys Res Commun. 2007 Sep 21;361(2):451-6. doi: 10.1016/j.bbrc.2007.07.029. Epub 2007 Jul 18. Biochem Biophys Res Commun. 2007. PMID: 17645871
157 results