Ohnmacht SA - Search Results

1

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A. Lavrado J, et al. Among authors: ohnmacht sa. Sci Rep. 2015 Apr 8;5:9696. doi: 10.1038/srep09696. Sci Rep. 2015. PMID: 25853628 Free PMC article.

2

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CM, Moreira R, dos Santos DJ, Neidle S, Paulo A. Lavrado J, et al. Among authors: ohnmacht sa. ChemMedChem. 2013 Oct;8(10):1648-61. doi: 10.1002/cmdc.201300288. Epub 2013 Aug 19. ChemMedChem. 2013. PMID: 23960016 Free article.

3

Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.

Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJ, Paulo A. Lavrado J, et al. Among authors: ohnmacht sa. ChemMedChem. 2015 May;10(5):836-49. doi: 10.1002/cmdc.201500067. Epub 2015 Mar 26. ChemMedChem. 2015. PMID: 25820698

4

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Brito H, et al. Among authors: ohnmacht sa. PLoS One. 2015 May 29;10(5):e0126891. doi: 10.1371/journal.pone.0126891. eCollection 2015. PLoS One. 2015. PMID: 26024321 Free PMC article.

5

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.

Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S. Ohnmacht SA, et al. Sci Rep. 2015 Jun 16;5:11385. doi: 10.1038/srep11385. Sci Rep. 2015. PMID: 26077929 Free PMC article.

6

A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells.

Ahmed AA, Marchetti C, Ohnmacht SA, Neidle S. Ahmed AA, et al. Among authors: ohnmacht sa. Sci Rep. 2020 Jul 22;10(1):12192. doi: 10.1038/s41598-020-68944-w. Sci Rep. 2020. PMID: 32699225 Free PMC article.

7

Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.

Ohnmacht SA, Micco M, Petrucci V, Todd AK, Reszka AP, Gunaratnam M, Carvalho MA, Zloh M, Neidle S. Ohnmacht SA, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5930-5. doi: 10.1016/j.bmcl.2012.07.065. Epub 2012 Jul 23. Bioorg Med Chem Lett. 2012. PMID: 22892119

8

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Micco M, Collie GW, Dale AG, Ohnmacht SA, Pazitna I, Gunaratnam M, Reszka AP, Neidle S. Micco M, et al. Among authors: ohnmacht sa. J Med Chem. 2013 Apr 11;56(7):2959-74. doi: 10.1021/jm301899y. Epub 2013 Apr 2. J Med Chem. 2013. PMID: 23514618

9

The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds.

Mpima S, Ohnmacht SA, Barletta M, Husby J, Pett LC, Gunaratnam M, Hilton ST, Neidle S. Mpima S, et al. Among authors: ohnmacht sa. Bioorg Med Chem. 2013 Oct 15;21(20):6162-70. doi: 10.1016/j.bmc.2013.05.027. Epub 2013 May 25. Bioorg Med Chem. 2013. PMID: 23769166

10

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands.

Ohnmacht SA, Ciancimino C, Vignaroli G, Gunaratnam M, Neidle S. Ohnmacht SA, et al. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5351-5. doi: 10.1016/j.bmcl.2013.07.057. Epub 2013 Aug 1. Bioorg Med Chem Lett. 2013. PMID: 23972440

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