Lavrado J - Search Results

1

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A. Lavrado J, et al. Sci Rep. 2015 Apr 8;5:9696. doi: 10.1038/srep09696. Sci Rep. 2015. PMID: 25853628 Free PMC article.

2

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CM, Moreira R, dos Santos DJ, Neidle S, Paulo A. Lavrado J, et al. ChemMedChem. 2013 Oct;8(10):1648-61. doi: 10.1002/cmdc.201300288. Epub 2013 Aug 19. ChemMedChem. 2013. PMID: 23960016 Free article.

3

Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.

Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJ, Paulo A. Lavrado J, et al. ChemMedChem. 2015 May;10(5):836-49. doi: 10.1002/cmdc.201500067. Epub 2015 Mar 26. ChemMedChem. 2015. PMID: 25820698

4

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Brito H, et al. Among authors: lavrado j. PLoS One. 2015 May 29;10(5):e0126891. doi: 10.1371/journal.pone.0126891. eCollection 2015. PLoS One. 2015. PMID: 26024321 Free PMC article.

5

Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells.

Mendes E, Cadoni E, Carneiro F, Afonso MB, Brito H, Lavrado J, Dos Santos DJVA, Vítor JB, Neidle S, Rodrigues CMP, Paulo A. Mendes E, et al. Among authors: lavrado j. ChemMedChem. 2019 Jul 17;14(14):1325-1328. doi: 10.1002/cmdc.201900243. Epub 2019 Jun 14. ChemMedChem. 2019. PMID: 31162877

6

Indoloquinolines as scaffolds for drug discovery.

Lavrado J, Moreira R, Paulo A. Lavrado J, et al. Curr Med Chem. 2010;17(22):2348-70. doi: 10.2174/092986710791698521. Curr Med Chem. 2010. PMID: 20491639 Review.

7

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.

Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. Lavrado J, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1378-81. doi: 10.1016/j.bmcl.2008.01.015. Epub 2008 Jan 9. Bioorg Med Chem Lett. 2008. PMID: 18207399

8

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization.

Lavrado J, Reszka AP, Moreira R, Neidle S, Paulo A. Lavrado J, et al. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7042-5. doi: 10.1016/j.bmcl.2010.09.110. Epub 2010 Sep 29. Bioorg Med Chem Lett. 2010. PMID: 20952194

9

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.

Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. Lavrado J, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6256-60. doi: 10.1016/j.bmcl.2012.07.104. Epub 2012 Aug 15. Bioorg Med Chem Lett. 2012. PMID: 22926067

10

Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities.

Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. Paulo A, et al. Among authors: lavrado j. J Med Chem. 2014 Apr 24;57(8):3295-313. doi: 10.1021/jm500075d. Epub 2014 Apr 15. J Med Chem. 2014. PMID: 24673163

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