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Structural insights into RNA processing by the human RISC-loading complex.
Wang HW, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA, Nogales E. Wang HW, et al. Among authors: taylor dw. Nat Struct Mol Biol. 2009 Nov;16(11):1148-53. doi: 10.1038/nsmb.1673. Epub 2009 Oct 11. Nat Struct Mol Biol. 2009. PMID: 19820710 Free PMC article.
Substrate-specific structural rearrangements of human Dicer.
Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA, Wang HW. Taylor DW, et al. Nat Struct Mol Biol. 2013 Jun;20(6):662-70. doi: 10.1038/nsmb.2564. Epub 2013 Apr 28. Nat Struct Mol Biol. 2013. PMID: 23624860 Free PMC article.
Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus.
Staals RHJ, Agari Y, Maki-Yonekura S, Zhu Y, Taylor DW, van Duijn E, Barendregt A, Vlot M, Koehorst JJ, Sakamoto K, Masuda A, Dohmae N, Schaap PJ, Doudna JA, Heck AJR, Yonekura K, van der Oost J, Shinkai A. Staals RHJ, et al. Among authors: taylor dw. Mol Cell. 2013 Oct 10;52(1):135-145. doi: 10.1016/j.molcel.2013.09.013. Mol Cell. 2013. PMID: 24119403 Free PMC article.
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Jinek M, et al. Among authors: taylor dw. Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6. Science. 2014. PMID: 24505130 Free PMC article.
RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus.
Staals RH, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, Urlaub H, Heck AJ, Nogales E, Doudna JA, Shinkai A, van der Oost J. Staals RH, et al. Among authors: taylor dw. Mol Cell. 2014 Nov 20;56(4):518-30. doi: 10.1016/j.molcel.2014.10.005. Epub 2014 Nov 6. Mol Cell. 2014. PMID: 25457165 Free PMC article.
Rational design of a split-Cas9 enzyme complex.
Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA. Wright AV, et al. Among authors: taylor dw. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2984-9. doi: 10.1073/pnas.1501698112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713377 Free PMC article.
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. Jiang F, et al. Among authors: taylor dw. Science. 2016 Feb 19;351(6275):867-71. doi: 10.1126/science.aad8282. Epub 2016 Jan 14. Science. 2016. PMID: 26841432 Free PMC article.
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.
Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA. Hochstrasser ML, et al. Among authors: taylor dw. Mol Cell. 2016 Sep 1;63(5):840-51. doi: 10.1016/j.molcel.2016.07.027. Mol Cell. 2016. PMID: 27588603 Free PMC article.
463 results