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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.
Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA. Brown NG, et al. Among authors: actis ml. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825779 Free PMC article.
Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.
Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA. Kamadurai HB, et al. Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828. Elife. 2013. PMID: 23936628 Free PMC article.
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. Inoue A, et al. J Biol Chem. 2014 Mar 7;289(10):7109-7120. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28. J Biol Chem. 2014. PMID: 24474685 Free PMC article.
16 results