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Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q. Li L, et al. Among authors: huang pq. Nat Chem Biol. 2015 May;11(5):339-46. doi: 10.1038/nchembio.1788. Epub 2015 Mar 30. Nat Chem Biol. 2015. PMID: 25822914 Free article.
A formal enantioselective total synthesis of FR901483.
Huo HH, Zhang HK, Xia XE, Huang PQ. Huo HH, et al. Among authors: huang pq. Org Lett. 2012 Sep 21;14(18):4834-7. doi: 10.1021/ol302165d. Epub 2012 Aug 31. Org Lett. 2012. PMID: 22937903
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.
Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q. Zhan YY, et al. Among authors: huang pq. Nat Chem Biol. 2012 Nov;8(11):897-904. doi: 10.1038/nchembio.1069. Epub 2012 Sep 16. Nat Chem Biol. 2012. PMID: 22983157
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q. Wang WJ, et al. Among authors: huang pq. Nat Chem Biol. 2014 Feb;10(2):133-40. doi: 10.1038/nchembio.1406. Epub 2013 Dec 8. Nat Chem Biol. 2014. PMID: 24316735
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. Zhou H, et al. Among authors: huang pq. Cancer Cell. 2010 Jun 15;17(6):560-73. doi: 10.1016/j.ccr.2010.04.023. Cancer Cell. 2010. PMID: 20541701 Free PMC article.
139 results