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The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: de palma am. PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25799064 Free PMC article.
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.
De Palma AM, Heggermont W, Leyssen P, Pürstinger G, Wimmer E, De Clercq E, Rao A, Monforte AM, Chimirri A, Neyts J. De Palma AM, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 2007 Feb 16;353(3):628-32. doi: 10.1016/j.bbrc.2006.12.063. Epub 2006 Dec 19. Biochem Biophys Res Commun. 2007. PMID: 17194441
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: de clercq e. J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12. J Virol. 2008. PMID: 18337578 Free PMC article.
Potential use of antiviral agents in polio eradication.
De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J. De Palma AM, et al. Among authors: de clercq e. Emerg Infect Dis. 2008 Apr;14(4):545-51. doi: 10.3201/eid1404.070439. Emerg Infect Dis. 2008. PMID: 18394270 Free PMC article.
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases.
Gruez A, Selisko B, Roberts M, Bricogne G, Bussetta C, Jabafi I, Coutard B, De Palma AM, Neyts J, Canard B. Gruez A, et al. Among authors: de palma am. J Virol. 2008 Oct;82(19):9577-90. doi: 10.1128/JVI.00631-08. Epub 2008 Jul 16. J Virol. 2008. PMID: 18632861 Free PMC article.
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: de clercq e. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. doi: 10.1128/AAC.00934-08. Epub 2009 Feb 23. Antimicrob Agents Chemother. 2009. PMID: 19237651 Free PMC article.
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.
Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, De Palma AM, Canard B, Neyts J, van Kuppeveld FJ. Ulferts R, et al. Among authors: de palma am. Antimicrob Agents Chemother. 2013 Apr;57(4):1952-6. doi: 10.1128/AAC.02084-12. Epub 2013 Jan 18. Antimicrob Agents Chemother. 2013. PMID: 23335743 Free PMC article.
Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase.
Jabafi I, Selisko B, Coutard B, De Palma AM, Neyts J, Egloff MP, Grisel S, Dalle K, Campanacci V, Spinelli S, Cambillau C, Canard B, Gruez A. Jabafi I, et al. Among authors: de palma am. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):495-8. doi: 10.1107/S1744309107020416. Epub 2007 May 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17554171 Free PMC article.
35 results