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Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats.
Chen L, McNulty J, Anderson D, Liu Y, Nystrom C, Bullard S, Collins J, Handlon AL, Klein R, Grimes A, Murray D, Brown R, Krull D, Benson B, Kleymenova E, Remlinger K, Young A, Yao X. Chen L, et al. Among authors: young a. J Pharmacol Exp Ther. 2010 Jul;334(1):164-70. doi: 10.1124/jpet.110.166892. Epub 2010 Apr 22. J Pharmacol Exp Ther. 2010. PMID: 20413600
Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.
Chen L, Yao X, Young A, McNulty J, Anderson D, Liu Y, Nystrom C, Croom D, Ross S, Collins J, Rajpal D, Hamlet K, Smith C, Gedulin B. Chen L, et al. Among authors: young a. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E68-76. doi: 10.1152/ajpendo.00323.2011. Epub 2011 Sep 20. Am J Physiol Endocrinol Metab. 2012. PMID: 21934041 Free article.
Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.
Wu Y, Aquino CJ, Cowan DJ, Anderson DL, Ambroso JL, Bishop MJ, Boros EE, Chen L, Cunningham A, Dobbins RL, Feldman PL, Harston LT, Kaldor IW, Klein R, Liang X, McIntyre MS, Merrill CL, Patterson KM, Prescott JS, Ray JS, Roller SG, Yao X, Young A, Yuen J, Collins JL. Wu Y, et al. Among authors: young a. J Med Chem. 2013 Jun 27;56(12):5094-114. doi: 10.1021/jm400459m. Epub 2013 Jun 6. J Med Chem. 2013. PMID: 23678871
7,798 results