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Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis.
J Biol Chem. 2015 May 15;290(20):12572-84. doi: 10.1074/jbc.M114.617894. Epub 2015 Mar 20.
J Biol Chem. 2015.
PMID: 25795778
Free PMC article.
Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.
Zboray L, Pluciennik A, Curtis D, Liu Y, Berman-Booty LD, Orr C, Kesler CT, Berger T, Gioeli D, Paschal BM, Merry DE.
Zboray L, et al.
Cell Rep. 2015 Dec 15;13(10):2312-23. doi: 10.1016/j.celrep.2015.11.019. Epub 2015 Dec 7.
Cell Rep. 2015.
PMID: 26673324
Free PMC article.
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