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Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties.
Nordin JZ, Lee Y, Vader P, Mäger I, Johansson HJ, Heusermann W, Wiklander OP, Hällbrink M, Seow Y, Bultema JJ, Gilthorpe J, Davies T, Fairchild PJ, Gabrielsson S, Meisner-Kober NC, Lehtiö J, Smith CI, Wood MJ, El Andaloussi S. Nordin JZ, et al. Among authors: wiklander op. Nanomedicine. 2015 May;11(4):879-83. doi: 10.1016/j.nano.2015.01.003. Epub 2015 Feb 4. Nanomedicine. 2015. PMID: 25659648 Free article.
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.
Wiklander OP, Nordin JZ, O'Loughlin A, Gustafsson Y, Corso G, Mäger I, Vader P, Lee Y, Sork H, Seow Y, Heldring N, Alvarez-Erviti L, Smith CI, Le Blanc K, Macchiarini P, Jungebluth P, Wood MJ, Andaloussi SE. Wiklander OP, et al. J Extracell Vesicles. 2015 Apr 20;4:26316. doi: 10.3402/jev.v4.26316. eCollection 2015. J Extracell Vesicles. 2015. PMID: 25899407 Free PMC article.
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo.
Bazaz S, Lehto T, Tops R, Gissberg O, Gupta D, Bestas B, Bost J, Wiklander OPB, Sork H, Zaghloul EM, Mamand DR, Hällbrink M, Sillard R, Saher O, Ezzat K, Smith CIE, Andaloussi SE, Lehto T. Bazaz S, et al. Biomedicines. 2021 Aug 19;9(8):1046. doi: 10.3390/biomedicines9081046. Biomedicines. 2021. PMID: 34440250 Free PMC article.
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Gupta D, Wiklander OPB, Görgens A, Conceição M, Corso G, Liang X, Seow Y, Balusu S, Feldin U, Bostancioglu B, Jawad R, Mamand DR, Lee YXF, Hean J, Mäger I, Roberts TC, Gustafsson M, Mohammad DK, Sork H, Backlund A, Lundin P, de Fougerolles A, Smith CIE, Wood MJA, Vandenbroucke RE, Nordin JZ, El-Andaloussi S. Gupta D, et al. Nat Biomed Eng. 2021 Sep;5(9):1084-1098. doi: 10.1038/s41551-021-00792-z. Epub 2021 Oct 6. Nat Biomed Eng. 2021. PMID: 34616047
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.
Sork H, Nordin JZ, Turunen JJ, Wiklander OP, Bestas B, Zaghloul EM, Margus H, Padari K, Duru AD, Corso G, Bost J, Vader P, Pooga M, Smith CE, Wood MJ, Schiffelers RM, Hällbrink M, Andaloussi SE. Sork H, et al. Among authors: wiklander op. Mol Ther Nucleic Acids. 2016 Mar 8;5(3):e290. doi: 10.1038/mtna.2016.8. Mol Ther Nucleic Acids. 2016. PMID: 27111416 Free PMC article.
37 results