Oruganty K - Search Results

1

Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics.

Hanold LE, Oruganty K, Ton NT, Beedle AM, Kannan N, Kennedy EJ. Hanold LE, et al. Among authors: oruganty k. PLoS One. 2015 Mar 19;10(3):e0118796. doi: 10.1371/journal.pone.0118796. eCollection 2015. PLoS One. 2015. PMID: 25790232 Free PMC article.

2

Design principles underpinning the regulatory diversity of protein kinases.

Oruganty K, Kannan N. Oruganty K, et al. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2529-39. doi: 10.1098/rstb.2012.0015. Philos Trans R Soc Lond B Biol Sci. 2012. PMID: 22889905 Free PMC article. Review.

3

Evolutionary variation and adaptation in a conserved protein kinase allosteric network: implications for inhibitor design.

Oruganty K, Kannan N. Oruganty K, et al. Biochim Biophys Acta. 2013 Jul;1834(7):1322-9. doi: 10.1016/j.bbapap.2013.02.040. Epub 2013 Mar 14. Biochim Biophys Acta. 2013. PMID: 23499783

4

Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.

Nguyen T, Ruan Z, Oruganty K, Kannan N. Nguyen T, et al. Among authors: oruganty k. PLoS One. 2015 Mar 23;10(3):e0119636. doi: 10.1371/journal.pone.0119636. eCollection 2015. PLoS One. 2015. PMID: 25799139 Free PMC article.

5

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Mohanty S, et al. Among authors: oruganty k. PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26925779 Free PMC article.

6

Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.

Oruganty K, Talathi NS, Wood ZA, Kannan N. Oruganty K, et al. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):924-9. doi: 10.1073/pnas.1207104110. Epub 2012 Dec 31. Proc Natl Acad Sci U S A. 2013. PMID: 23277537 Free PMC article.

7

Deciphering the structural basis of eukaryotic protein kinase regulation.

Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. Meharena HS, et al. Among authors: oruganty k. PLoS Biol. 2013 Oct;11(10):e1001680. doi: 10.1371/journal.pbio.1001680. Epub 2013 Oct 15. PLoS Biol. 2013. PMID: 24143133 Free PMC article.

8

Identification and classification of small molecule kinases: insights into substrate recognition and specificity.

Oruganty K, Talevich EE, Neuwald AF, Kannan N. Oruganty K, et al. BMC Evol Biol. 2016 Jan 6;16:7. doi: 10.1186/s12862-015-0576-x. BMC Evol Biol. 2016. PMID: 26738562 Free PMC article.

9

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.

Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA. Bailey FP, et al. Among authors: oruganty k. Biochem J. 2015 Apr 1;467(1):47-62. doi: 10.1042/BJ20141441. Biochem J. 2015. PMID: 25583260 Free PMC article.

10

Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.

Stefely JA, Reidenbach AG, Ulbrich A, Oruganty K, Floyd BJ, Jochem A, Saunders JM, Johnson IE, Minogue CE, Wrobel RL, Barber GE, Lee D, Li S, Kannan N, Coon JJ, Bingman CA, Pagliarini DJ. Stefely JA, et al. Among authors: oruganty k. Mol Cell. 2015 Jan 8;57(1):83-94. doi: 10.1016/j.molcel.2014.11.002. Epub 2014 Dec 11. Mol Cell. 2015. PMID: 25498144 Free PMC article.

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