Kobe B - Search Results

1

Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach.

Bajaj M, Mamidyala SK, Zuegg J, Begg SL, Ween MP, Luo Z, Huang JX, McEwan AG, Kobe B, Paton JC, McDevitt CA, Cooper MA. Bajaj M, et al. Among authors: kobe b. ACS Chem Biol. 2015 Jun 19;10(6):1511-20. doi: 10.1021/cb501032x. Epub 2015 Mar 30. ACS Chem Biol. 2015. PMID: 25786639

2

A molecular mechanism for bacterial susceptibility to zinc.

McDevitt CA, Ogunniyi AD, Valkov E, Lawrence MC, Kobe B, McEwan AG, Paton JC. McDevitt CA, et al. Among authors: kobe b. PLoS Pathog. 2011 Nov;7(11):e1002357. doi: 10.1371/journal.ppat.1002357. Epub 2011 Nov 3. PLoS Pathog. 2011. PMID: 22072971 Free PMC article.

3

Prokaryotic substrate-binding proteins as targets for antimicrobial therapies.

Couñago RM, McDevitt CA, Ween MP, Kobe B. Couñago RM, et al. Among authors: kobe b. Curr Drug Targets. 2012 Oct;13(11):1400-10. doi: 10.2174/138945012803530170. Curr Drug Targets. 2012. PMID: 22664093

4

A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms.

Chen NH, Couñago RM, Djoko KY, Jennings MP, Apicella MA, Kobe B, McEwan AG. Chen NH, et al. Among authors: kobe b. Antioxid Redox Signal. 2013 Mar 1;18(7):743-55. doi: 10.1089/ars.2012.4749. Epub 2012 Nov 20. Antioxid Redox Signal. 2013. PMID: 22937752 Free PMC article.

5

Imperfect coordination chemistry facilitates metal ion release in the Psa permease.

Couñago RM, Ween MP, Begg SL, Bajaj M, Zuegg J, O'Mara ML, Cooper MA, McEwan AG, Paton JC, Kobe B, McDevitt CA. Couñago RM, et al. Among authors: kobe b. Nat Chem Biol. 2014 Jan;10(1):35-41. doi: 10.1038/nchembio.1382. Epub 2013 Nov 10. Nat Chem Biol. 2014. PMID: 24212134

6

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae.

Plumptre CD, Eijkelkamp BA, Morey JR, Behr F, Couñago RM, Ogunniyi AD, Kobe B, O'Mara ML, Paton JC, McDevitt CA. Plumptre CD, et al. Among authors: kobe b. Mol Microbiol. 2014 Feb;91(4):834-51. doi: 10.1111/mmi.12504. Epub 2014 Jan 16. Mol Microbiol. 2014. PMID: 24428621 Free article.

7

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.

Begg SL, Eijkelkamp BA, Luo Z, Couñago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA. Begg SL, et al. Among authors: kobe b. Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418. Nat Commun. 2015. PMID: 25731976 Free PMC article.

8

Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy.

Deplazes E, Begg SL, van Wonderen JH, Campbell R, Kobe B, Paton JC, MacMillan F, McDevitt CA, O'Mara ML. Deplazes E, et al. Among authors: kobe b. Biophys Chem. 2015 Dec;207:51-60. doi: 10.1016/j.bpc.2015.08.004. Epub 2015 Sep 3. Biophys Chem. 2015. PMID: 26379256

9

Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA.

Luo Z, Morey JR, McDevitt CA, Kobe B. Luo Z, et al. Among authors: kobe b. Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1459-64. doi: 10.1107/S2053230X15021330. Epub 2015 Nov 18. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26625286 Free PMC article.

10

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region.

Couñago RM, Chen NH, Chang CW, Djoko KY, McEwan AG, Kobe B. Couñago RM, et al. Among authors: kobe b. Nucleic Acids Res. 2016 Aug 19;44(14):6981-93. doi: 10.1093/nar/gkw543. Epub 2016 Jun 15. Nucleic Acids Res. 2016. PMID: 27307602 Free PMC article.

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