Li H - Search Results

1

Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.

Oresic Bender K, Ofori L, van der Linden WA, Mock ED, Datta GK, Chowdhury S, Li H, Segal E, Sanchez Lopez M, Ellman JA, Figdor CG, Bogyo M, Verdoes M. Oresic Bender K, et al. Among authors: li h. J Am Chem Soc. 2015 Apr 15;137(14):4771-7. doi: 10.1021/jacs.5b00315. Epub 2015 Apr 1. J Am Chem Soc. 2015. PMID: 25785540 Free PMC article.

2

Proteases as regulators of pathogenesis: examples from the Apicomplexa.

Li H, Child MA, Bogyo M. Li H, et al. Biochim Biophys Acta. 2012 Jan;1824(1):177-85. doi: 10.1016/j.bbapap.2011.06.002. Epub 2011 Jun 13. Biochim Biophys Acta. 2012. PMID: 21683169 Free PMC article. Review.

3

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity.

Li H, Ponder EL, Verdoes M, Asbjornsdottir KH, Deu E, Edgington LE, Lee JT, Kirk CJ, Demo SD, Williamson KC, Bogyo M. Li H, et al. Chem Biol. 2012 Dec 21;19(12):1535-45. doi: 10.1016/j.chembiol.2012.09.019. Epub 2012 Nov 8. Chem Biol. 2012. PMID: 23142757 Free PMC article.

4

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.

Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. Deu E, et al. Among authors: li h. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18244-9. doi: 10.1073/pnas.1312782110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145449 Free PMC article.

5

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes.

Li H, van der Linden WA, Verdoes M, Florea BI, McAllister FE, Govindaswamy K, Elias JE, Bhanot P, Overkleeft HS, Bogyo M. Li H, et al. ACS Chem Biol. 2014 Aug 15;9(8):1869-76. doi: 10.1021/cb5001263. Epub 2014 Jun 19. ACS Chem Biol. 2014. PMID: 24918547 Free PMC article.

6

Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome.

Li H, Tsu C, Blackburn C, Li G, Hales P, Dick L, Bogyo M. Li H, et al. Among authors: li g. J Am Chem Soc. 2014 Oct 1;136(39):13562-5. doi: 10.1021/ja507692y. Epub 2014 Sep 19. J Am Chem Soc. 2014. PMID: 25226494 Free PMC article.

7

A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells.

Roth A, Li H, Anorma C, Chan J. Roth A, et al. Among authors: li h. J Am Chem Soc. 2015 Sep 2;137(34):10890-3. doi: 10.1021/jacs.5b05339. Epub 2015 Aug 25. J Am Chem Soc. 2015. PMID: 26305899

8

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.

Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. Lauterwasser EM, et al. Among authors: li h. ACS Med Chem Lett. 2015 Oct 2;6(11):1145-9. doi: 10.1021/acsmedchemlett.5b00296. eCollection 2015 Nov 12. ACS Med Chem Lett. 2015. PMID: 26617969 Free PMC article.

9

Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes.

Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K, Yao S, Wu P, Li F, Huang H, Xu Z, Wolters PJ, Rosen GD, Collard HR, Zhu Z, Cheng Z, Bogyo M. Withana NP, et al. Among authors: li f, li h. Sci Rep. 2016 Jan 22;6:19755. doi: 10.1038/srep19755. Sci Rep. 2016. PMID: 26797565 Free PMC article.

10

Structure- and function-based design of Plasmodium-selective proteasome inhibitors.

Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. Li H, et al. Nature. 2016 Feb 11;530(7589):233-6. doi: 10.1038/nature16936. Nature. 2016. PMID: 26863983 Free PMC article.

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