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Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.
Chromikova V, Mader A, Hofbauer S, Göbl C, Madl T, Gach JS, Bauernfried S, Furtmüller PG, Forthal DN, Mach L, Obinger C, Kunert R. Chromikova V, et al. Among authors: mach l. Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1536-44. doi: 10.1016/j.bbapap.2015.02.018. Epub 2015 Mar 5. Biochim Biophys Acta. 2015. PMID: 25748881 Free PMC article.
Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure.
Strasser R, Stadlmann J, Schähs M, Stiegler G, Quendler H, Mach L, Glössl J, Weterings K, Pabst M, Steinkellner H. Strasser R, et al. Among authors: mach l. Plant Biotechnol J. 2008 May;6(4):392-402. doi: 10.1111/j.1467-7652.2008.00330.x. Epub 2008 Mar 13. Plant Biotechnol J. 2008. PMID: 18346095 Free article.
The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms.
Niemer M, Mehofer U, Torres Acosta JA, Verdianz M, Henkel T, Loos A, Strasser R, Maresch D, Rademacher T, Steinkellner H, Mach L. Niemer M, et al. Among authors: mach l. Biotechnol J. 2014 Apr;9(4):493-500. doi: 10.1002/biot.201300207. Biotechnol J. 2014. PMID: 24478053 Free PMC article.
Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol.
Megson ZA, Pittenauer E, Duda KA, Engel R, Ortmayr K, Koellensperger G, Mach L, Allmaier G, Holst O, Messner P, Schäffer C. Megson ZA, et al. Among authors: mach l. Biochim Biophys Acta. 2015 Nov;1851(11):1417-27. doi: 10.1016/j.bbalip.2015.08.004. Epub 2015 Aug 13. Biochim Biophys Acta. 2015. PMID: 26277409 Free PMC article.
Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.
Loos A, Gach JS, Hackl T, Maresch D, Henkel T, Porodko A, Bui-Minh D, Sommeregger W, Wozniak-Knopp G, Forthal DN, Altmann F, Steinkellner H, Mach L. Loos A, et al. Among authors: mach l. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12675-80. doi: 10.1073/pnas.1509090112. Epub 2015 Sep 28. Proc Natl Acad Sci U S A. 2015. PMID: 26417081 Free PMC article.
The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B.
Paireder M, Tholen S, Porodko A, Biniossek ML, Mayer B, Novinec M, Schilling O, Mach L. Paireder M, et al. Among authors: mach l. Biochim Biophys Acta Proteins Proteom. 2017 Apr;1865(4):444-452. doi: 10.1016/j.bbapap.2017.02.007. Epub 2017 Feb 7. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 28188928 Free article.
138 results