Ward RA - Search Results

1

Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.

Kettle JG, Ballard P, Bardelle C, Cockerill M, Colclough N, Critchlow SE, Debreczeni J, Fairley G, Fillery S, Graham MA, Goodwin L, Guichard S, Hudson K, Ward RA, Whittaker D. Kettle JG, et al. Among authors: ward ra. J Med Chem. 2015 Mar 26;58(6):2834-44. doi: 10.1021/acs.jmedchem.5b00098. Epub 2015 Mar 12. J Med Chem. 2015. PMID: 25738750

2

Structure-based virtual screening for low molecular weight chemical starting points for dipeptidyl peptidase IV inhibitors.

Ward RA, Perkins TD, Stafford J. Ward RA, et al. J Med Chem. 2005 Nov 3;48(22):6991-6. doi: 10.1021/jm0505866. J Med Chem. 2005. PMID: 16250657

3

Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations.

Avizienyte E, Ward RA, Garner AP. Avizienyte E, et al. Among authors: ward ra. Biochem J. 2008 Oct 15;415(2):197-206. doi: 10.1042/BJ20080728. Biochem J. 2008. PMID: 18588508

4

Rapid generation of a high quality lead for transforming growth factor-beta (TGF-beta) type I receptor (ALK5).

Goldberg FW, Ward RA, Powell SJ, Debreczeni JE, Norman RA, Roberts NJ, Dishington AP, Gingell HJ, Wickson KF, Roberts AL. Goldberg FW, et al. Among authors: ward ra. J Med Chem. 2009 Dec 10;52(23):7901-5. doi: 10.1021/jm900807w. J Med Chem. 2009. PMID: 19736928

5

Toward the comprehensive systematic enumeration and synthesis of novel kinase inhibitors based on a 4-anilinoquinazoline binding mode.

Kettle JG, Ward RA. Kettle JG, et al. Among authors: ward ra. J Chem Inf Model. 2010 Apr 26;50(4):525-33. doi: 10.1021/ci9004767. J Chem Inf Model. 2010. PMID: 20141221

6

Enzymatic characterisation of USP7 deubiquitinating activity and inhibition.

Wrigley JD, Eckersley K, Hardern IM, Millard L, Walters M, Peters SW, Mott R, Nowak T, Ward RA, Simpson PB, Hudson K. Wrigley JD, et al. Among authors: ward ra. Cell Biochem Biophys. 2011 Jun;60(1-2):99-111. doi: 10.1007/s12013-011-9186-4. Cell Biochem Biophys. 2011. PMID: 21468692

7

Systematic enumeration of heteroaromatic ring systems as reagents for use in medicinal chemistry.

Ward RA, Kettle JG. Ward RA, et al. J Med Chem. 2011 Jul 14;54(13):4670-7. doi: 10.1021/jm200338a. Epub 2011 Jun 8. J Med Chem. 2011. PMID: 21650161

8

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.

Ward RA, Brassington C, Breeze AL, Caputo A, Critchlow S, Davies G, Goodwin L, Hassall G, Greenwood R, Holdgate GA, Mrosek M, Norman RA, Pearson S, Tart J, Tucker JA, Vogtherr M, Whittaker D, Wingfield J, Winter J, Hudson K. Ward RA, et al. J Med Chem. 2012 Apr 12;55(7):3285-306. doi: 10.1021/jm201734r. Epub 2012 Mar 26. J Med Chem. 2012. PMID: 22417091

9

Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR).

Ward RA, Anderton MJ, Ashton S, Bethel PA, Box M, Butterworth S, Colclough N, Chorley CG, Chuaqui C, Cross DA, Dakin LA, Debreczeni JÉ, Eberlein C, Finlay MR, Hill GB, Grist M, Klinowska TC, Lane C, Martin S, Orme JP, Smith P, Wang F, Waring MJ. Ward RA, et al. J Med Chem. 2013 Sep 12;56(17):7025-48. doi: 10.1021/jm400822z. Epub 2013 Aug 30. J Med Chem. 2013. PMID: 23930994

10

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

Cross DA, Ashton SE, Ghiorghiu S, Eberlein C, Nebhan CA, Spitzler PJ, Orme JP, Finlay MR, Ward RA, Mellor MJ, Hughes G, Rahi A, Jacobs VN, Red Brewer M, Ichihara E, Sun J, Jin H, Ballard P, Al-Kadhimi K, Rowlinson R, Klinowska T, Richmond GH, Cantarini M, Kim DW, Ranson MR, Pao W. Cross DA, et al. Among authors: ward ra. Cancer Discov. 2014 Sep;4(9):1046-61. doi: 10.1158/2159-8290.CD-14-0337. Epub 2014 Jun 3. Cancer Discov. 2014. PMID: 24893891 Free PMC article.

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