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A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. Weissmiller AM, et al. Among authors: mobley wc. PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015. PLoS One. 2015. PMID: 25710492 Free PMC article.
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Salehi A, et al. Among authors: mobley wc. Neuron. 2006 Jul 6;51(1):29-42. doi: 10.1016/j.neuron.2006.05.022. Neuron. 2006. PMID: 16815330 Free article.
The coming of age of axonal neurotrophin signaling endosomes.
Wu C, Cui B, He L, Chen L, Mobley WC. Wu C, et al. Among authors: mobley wc. J Proteomics. 2009 Feb 15;72(1):46-55. doi: 10.1016/j.jprot.2008.10.007. Epub 2008 Nov 6. J Proteomics. 2009. PMID: 19028611 Free PMC article. Review.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Among authors: mobley wc. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.
236 results