Ward SE - Search Results

1

Therapeutic opportunities within the DNA damage response.

Pearl LH, Schierz AC, Ward SE, Al-Lazikani B, Pearl FM. Pearl LH, et al. Among authors: ward se. Nat Rev Cancer. 2015 Mar;15(3):166-80. doi: 10.1038/nrc3891. Nat Rev Cancer. 2015. PMID: 25709118 Free article. Review.

2

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.

Chen X, Ali YI, Fisher CE, Arribas-Bosacoma R, Rajasekaran MB, Williams G, Walker S, Booth JR, Hudson JJ, Roe SM, Pearl LH, Ward SE, Pearl FM, Oliver AW. Chen X, et al. Among authors: ward se. Elife. 2021 Mar 1;10:e65339. doi: 10.7554/eLife.65339. Elife. 2021. PMID: 33647232 Free PMC article.

3

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Among authors: ward se. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.

4

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.

Ocasio CA, Rajasekaran MB, Walker S, Le Grand D, Spencer J, Pearl FM, Ward SE, Savic V, Pearl LH, Hochegger H, Oliver AW. Ocasio CA, et al. Among authors: ward se. Oncotarget. 2016 Nov 1;7(44):71182-71197. doi: 10.18632/oncotarget.11511. Oncotarget. 2016. PMID: 27563826 Free PMC article.

5

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S, Atack JR. Walker S, et al. Anal Biochem. 2014 Jun 1;454(100):17-22. doi: 10.1016/j.ab.2014.03.004. Epub 2014 Mar 14. Anal Biochem. 2014. PMID: 24637157 Free PMC article.

6

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan.

Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE, El-Khamisy SF. Meisenberg C, et al. Among authors: ward se. Mol Cancer Ther. 2015 Feb;14(2):575-85. doi: 10.1158/1535-7163.MCT-14-0762. Epub 2014 Dec 18. Mol Cancer Ther. 2015. PMID: 25522766 Free PMC article.

7

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.

Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Meisenberg C, et al. Among authors: ward se. Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026. Nucleic Acids Res. 2017. PMID: 28180300 Free PMC article.

8

TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan.

Meisenberg C, Ward SE, Schmid P, El-Khamisy SF. Meisenberg C, et al. Among authors: ward se. J Cancer Sci Ther. 2014 Jul 25;6(7):258-267. doi: 10.4172/1948-5956.1000280. J Cancer Sci Ther. 2014. PMID: 25232464 Free PMC article.

9

CCRK is a novel signalling hub exploitable in cancer immunotherapy.

Mok MT, Zhou J, Tang W, Zeng X, Oliver AW, Ward SE, Cheng AS. Mok MT, et al. Among authors: ward se. Pharmacol Ther. 2018 Jun;186:138-151. doi: 10.1016/j.pharmthera.2018.01.008. Epub 2018 Mar 1. Pharmacol Ther. 2018. PMID: 29360538 Review.

10

AMPA Receptor Positive Allosteric Modulators: Potential for the Treatment of Neuropsychiatric and Neurological Disorders.

Reuillon T, Ward SE, Beswick P. Reuillon T, et al. Among authors: ward se. Curr Top Med Chem. 2016;16(29):3536-3565. doi: 10.2174/1568026616666160627114507. Curr Top Med Chem. 2016. PMID: 27363568

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