Heler R - Search Results

1

Cas9 specifies functional viral targets during CRISPR-Cas adaptation.

Heler R, Samai P, Modell JW, Weiner C, Goldberg GW, Bikard D, Marraffini LA. Heler R, et al. Nature. 2015 Mar 12;519(7542):199-202. doi: 10.1038/nature14245. Epub 2015 Feb 18. Nature. 2015. PMID: 25707807 Free PMC article.

2

Adapting to new threats: the generation of memory by CRISPR-Cas immune systems.

Heler R, Marraffini LA, Bikard D. Heler R, et al. Mol Microbiol. 2014 Jul;93(1):1-9. doi: 10.1111/mmi.12640. Epub 2014 Jun 4. Mol Microbiol. 2014. PMID: 24806524 Free PMC article. Review.

3

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.

Heler R, Wright AV, Vucelja M, Bikard D, Doudna JA, Marraffini LA. Heler R, et al. Mol Cell. 2017 Jan 5;65(1):168-175. doi: 10.1016/j.molcel.2016.11.031. Epub 2016 Dec 22. Mol Cell. 2017. PMID: 28017588 Free PMC article.

4

Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response.

Heler R, Wright AV, Vucelja M, Doudna JA, Marraffini LA. Heler R, et al. Cell Host Microbe. 2019 Feb 13;25(2):242-249.e3. doi: 10.1016/j.chom.2018.12.016. Epub 2019 Jan 29. Cell Host Microbe. 2019. PMID: 30709780 Free PMC article.

5

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.

Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A. Maji B, et al. Among authors: heler r. Cell. 2019 May 2;177(4):1067-1079.e19. doi: 10.1016/j.cell.2019.04.009. Cell. 2019. PMID: 31051099 Free PMC article.

6

Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.

Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ. Clarke R, et al. Among authors: heler r. Mol Cell. 2018 Jul 5;71(1):42-55.e8. doi: 10.1016/j.molcel.2018.06.005. Mol Cell. 2018. PMID: 29979968 Free PMC article.

7

Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels.

Heler R, Bell JK, Boland LM. Heler R, et al. Channels (Austin). 2013 Mar-Apr;7(2):74-84. doi: 10.4161/chan.23453. Epub 2013 Jan 18. Channels (Austin). 2013. PMID: 23334377 Free PMC article.

8

A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge.

Wells GD, Tang QY, Heler R, Tompkins-MacDonald GJ, Pritchard EN, Leys SP, Logothetis DE, Boland LM. Wells GD, et al. Among authors: heler r. J Exp Biol. 2012 Jul 15;215(Pt 14):2435-44. doi: 10.1242/jeb.066233. J Exp Biol. 2012. PMID: 22723483 Free PMC article.

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