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AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M. Gardner MR, et al. Among authors: fuchs sp. Nature. 2015 Mar 5;519(7541):87-91. doi: 10.1038/nature14264. Epub 2015 Feb 18. Nature. 2015. PMID: 25707797 Free PMC article.
A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus.
Magnani DM, Silveira CGT, Rosen BC, Ricciardi MJ, Pedreño-Lopez N, Gutman MJ, Bailey VK, Maxwell HS, Domingues A, Gonzalez-Nieto L, Avelino-Silva VI, Trindade M, Nogueira J, Oliveira CS, Maestri A, Felix AC, Levi JE, Nogueira ML, Martins MA, Martinez-Navio JM, Fuchs SP, Whitehead SS, Burton DR, Desrosiers RC, Kallas EG, Watkins DI. Magnani DM, et al. Among authors: fuchs sp. PLoS Negl Trop Dis. 2017 Jun 12;11(6):e0005655. doi: 10.1371/journal.pntd.0005655. eCollection 2017 Jun. PLoS Negl Trop Dis. 2017. PMID: 28604797 Free PMC article.
Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys.
Magnani DM, Ricciardi MJ, Bailey VK, Gutman MJ, Pedreño-Lopez N, Silveira CGT, Maxwell HS, Domingues A, Gonzalez-Nieto L, Su Q, Newman RM, Pack M, Martins MA, Martinez-Navio JM, Fuchs SP, Rakasz EG, Allen TM, Whitehead SS, Burton DR, Gao G, Desrosiers RC, Kallas EG, Watkins DI. Magnani DM, et al. Among authors: fuchs sp. Mol Ther. 2017 Oct 4;25(10):2323-2331. doi: 10.1016/j.ymthe.2017.06.020. Epub 2017 Jul 24. Mol Ther. 2017. PMID: 28750738 Free PMC article.
Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine.
Magnani DM, Silveira CGT, Ricciardi MJ, Gonzalez-Nieto L, Pedreño-Lopez N, Bailey VK, Gutman MJ, Maxwell HS, Domingues A, Costa PR, Ferrari L, Goulart R, Martins MA, Martinez-Navio JM, Fuchs SP, Kalil J, Timenetsky MDC, Wrammert J, Whitehead SS, Burton DR, Desrosiers RC, Kallas EG, Watkins DI. Magnani DM, et al. Among authors: fuchs sp. J Virol. 2017 Oct 27;91(22):e00867-17. doi: 10.1128/JVI.00867-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28878078 Free PMC article. Clinical Trial.
Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies.
Gardner MR, Fetzer I, Kattenhorn LM, Davis-Gardner ME, Zhou AS, Alfant B, Weber JA, Kondur HR, Martinez-Navio JM, Fuchs SP, Desrosiers RC, Gao G, Lifson JD, Farzan M. Gardner MR, et al. Among authors: fuchs sp. Mol Ther. 2019 Mar 6;27(3):650-660. doi: 10.1016/j.ymthe.2019.01.004. Epub 2019 Jan 12. Mol Ther. 2019. PMID: 30704961 Free PMC article.
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