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The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates.
Oshima S, Karrer EE, Kawato Y, Maeda M, Fukahori H, Tsujimoto S, Hirose J, Nakamura K, Marui T, Takamura F, Noto T, Chapin SJ, Fujii Y, Neighbors M, Viswanathan S, Devens BH, Higashi Y. Oshima S, et al. Among authors: karrer ee. Transplantation. 2016 Dec;100(12):2611-2620. doi: 10.1097/TP.0000000000001397. Transplantation. 2016. PMID: 27861289
ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.
Oshima S, Karrer EE, Paidhungat MM, Neighbors M, Chapin SJ, Fan RA, Reed MA, Wu K, Wong C, Chen Y, Whitlow M, Anderson FA, Bam RA, Zhang Q, Larsen BR, Viswanathan S, Devens BH, Bass SH, Higashi Y. Oshima S, et al. Among authors: karrer ee. Protein Eng Des Sel. 2016 May;29(5):159-67. doi: 10.1093/protein/gzw002. Epub 2016 Mar 10. Protein Eng Des Sel. 2016. PMID: 26968452
Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of ASP2408, a Potent Selective T-Cell Costimulation Modulator After Single and Multiple Ascending Doses in Healthy Volunteers and RA Patients.
Zhu T, Keirns J, Howieson C, Kaibara A, Goldwater R, Kivitz AJ, Chindalore V, Cohen S, Santos V, Akinlade B, Kernstock R, Delgado-Herrera L, Blahunka PC, Karrer EE, Garg JP, Samberg N, Zeiher BG. Zhu T, et al. Among authors: karrer ee. Clin Pharmacol Drug Dev. 2016 Sep;5(5):408-25. doi: 10.1002/cpdd.251. Epub 2016 Mar 28. Clin Pharmacol Drug Dev. 2016. PMID: 27410490 Clinical Trial.
A Phase 1 Dose-Escalation Study of ASP2409, a Selective T-Cell Costimulation Inhibitor, in Stable Rheumatoid Arthritis Patients on Methotrexate Therapy.
Zhang W, Kernstock RM, Karrer EE, Cohen SB, Chindalore VL, Kivitz AJ, Blahunka PC, Delgado-Herrera L, Zeiher BG, Samberg NL, Garg JP. Zhang W, et al. Among authors: karrer ee. Clin Pharmacol Drug Dev. 2016 Jul;5(4):259-68. doi: 10.1002/cpdd.237. Epub 2016 Jan 8. Clin Pharmacol Drug Dev. 2016. PMID: 27310327 Clinical Trial.
29 results