Keinänen TA - Search Results

1

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Hyvönen MT, Khomutov M, Petit M, Weisell J, Kochetkov SN, Alhonen L, Vepsäläinen J, Khomutov AR, Keinänen TA. Hyvönen MT, et al. Among authors: keinanen ta. ACS Chem Biol. 2015 Jun 19;10(6):1417-24. doi: 10.1021/cb500938e. Epub 2015 Feb 27. ACS Chem Biol. 2015. PMID: 25689365

2

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J. Keinänen TA, et al. Mini Rev Med Chem. 2007 Aug;7(8):813-20. doi: 10.2174/138955707781387867. Mini Rev Med Chem. 2007. PMID: 17692042 Review.

3

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J. Hyvönen MT, et al. Among authors: keinanen ta. J Biol Chem. 2007 Nov 30;282(48):34700-6. doi: 10.1074/jbc.M704282200. Epub 2007 Sep 27. J Biol Chem. 2007. PMID: 17901051 Free article.

4

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR. Weisell J, et al. Among authors: keinanen ta. J Med Chem. 2010 Aug 12;53(15):5738-48. doi: 10.1021/jm100439p. J Med Chem. 2010. PMID: 20684609

5

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Weisell J, Kochetkov SN, Vepsäläinen J, Alhonen L, Khomutov AR. Hyvönen MT, et al. Among authors: keinanen ta. J Med Chem. 2011 Jul 14;54(13):4611-8. doi: 10.1021/jm200293r. Epub 2011 Jun 3. J Med Chem. 2011. PMID: 21639123

6

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Vepsäläinen J, Park JH, Khomutov AR, Alhonen L, Park MH. Hyvönen MT, et al. Among authors: keinanen ta. Amino Acids. 2012 Feb;42(2-3):685-95. doi: 10.1007/s00726-011-0984-1. Epub 2011 Aug 23. Amino Acids. 2012. PMID: 21861168 Free PMC article.

7

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators.

Keinänen TA, Grigorenko N, Khomutov AR, Huang Q, Uimari A, Alhonen L, Hyvönen MT, Vepsäläinen J. Keinänen TA, et al. Biosci Rep. 2018 Aug 29;38(4):BSR20180527. doi: 10.1042/BSR20180527. Print 2018 Aug 31. Biosci Rep. 2018. PMID: 30006473 Free PMC article.

8

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives.

Khomutov M, Hyvönen MT, Simonian A, Formanovsky AA, Mikhura IV, Chizhov AO, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR. Khomutov M, et al. Among authors: keinanen ta. J Med Chem. 2019 Dec 26;62(24):11335-11347. doi: 10.1021/acs.jmedchem.9b01666. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31765147 Free PMC article.

9

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation.

Hyvönen MT, Khomutov M, Vepsäläinen J, Khomutov AR, Keinänen TA. Hyvönen MT, et al. Among authors: keinanen ta. Biomolecules. 2021 May 10;11(5):707. doi: 10.3390/biom11050707. Biomolecules. 2021. PMID: 34068700 Free PMC article.

10

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. Khomutov MA, et al. Among authors: keinanen ta. Biochemistry (Mosc). 2013 Dec;78(13):1431-46. doi: 10.1134/S0006297913130051. Biochemistry (Mosc). 2013. PMID: 24490733 Free article. Review.

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