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daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.
Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, Riedinger C, Schwenger V, Herzig S, Hecker M, Tyedmers J, Nawroth PP, Morcos M. Mendler M, et al. Among authors: bierhaus a. Diabetologia. 2015 Feb;58(2):393-401. doi: 10.1007/s00125-014-3415-5. Epub 2014 Oct 17. Diabetologia. 2015. PMID: 25322843
Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes.
Forbes JM, Söderlund J, Yap FY, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop PH. Forbes JM, et al. Among authors: bierhaus a. Diabetologia. 2011 May;54(5):1032-42. doi: 10.1007/s00125-011-2058-z. Epub 2011 Feb 6. Diabetologia. 2011. PMID: 21298413
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. Sourris KC, et al. Among authors: bierhaus a. Diabetologia. 2010 Nov;53(11):2442-51. doi: 10.1007/s00125-010-1837-2. Epub 2010 Jul 15. Diabetologia. 2010. PMID: 20631980 Free PMC article.
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.
Morcos M, Du X, Pfisterer F, Hutter H, Sayed AA, Thornalley P, Ahmed N, Baynes J, Thorpe S, Kukudov G, Schlotterer A, Bozorgmehr F, El Baki RA, Stern D, Moehrlen F, Ibrahim Y, Oikonomou D, Hamann A, Becker C, Zeier M, Schwenger V, Miftari N, Humpert P, Hammes HP, Buechler M, Bierhaus A, Brownlee M, Nawroth PP. Morcos M, et al. Among authors: bierhaus a. Aging Cell. 2008 Mar;7(2):260-9. doi: 10.1111/j.1474-9726.2008.00371.x. Epub 2008 Jan 21. Aging Cell. 2008. PMID: 18221415 Free article.
Methylglyoxal evokes pain by stimulating TRPA1.
Andersson DA, Gentry C, Light E, Vastani N, Vallortigara J, Bierhaus A, Fleming T, Bevan S. Andersson DA, et al. Among authors: bierhaus a. PLoS One. 2013 Oct 22;8(10):e77986. doi: 10.1371/journal.pone.0077986. eCollection 2013. PLoS One. 2013. PMID: 24167592 Free PMC article.
249 results