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A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.
Sakai K, Sekizuka T, Ami Y, Nakajima N, Kitazawa M, Sato Y, Nakajima K, Anraku M, Kubota T, Komase K, Takehara K, Hasegawa H, Odagiri T, Tashiro M, Kuroda M, Takeda M. Sakai K, et al. Among authors: kubota t. J Virol. 2015 May;89(9):5154-8. doi: 10.1128/JVI.00124-15. Epub 2015 Feb 11. J Virol. 2015. PMID: 25673722 Free PMC article.
The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.
Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M. Sakai K, et al. Among authors: kubota t. J Virol. 2014 May;88(10):5608-16. doi: 10.1128/JVI.03677-13. Epub 2014 Mar 5. J Virol. 2014. PMID: 24600012 Free PMC article.
Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.
Kubota T, Yokosawa N, Yokota S, Fujii N, Tashiro M, Kato A. Kubota T, et al. J Virol. 2005 Apr;79(7):4451-9. doi: 10.1128/JVI.79.7.4451-4459.2005. J Virol. 2005. PMID: 15767445 Free PMC article.
Mumps virus (MuV) has been shown to antagonize the antiviral effects of interferon (IFN) through proteasome-mediated complete degradation of STAT1 by using the viral V protein (T. Kubota et al., Biochem. Biophys. Res. Commun. 283:255-259, 2001). However, we found th …
Mumps virus (MuV) has been shown to antagonize the antiviral effects of interferon (IFN) through proteasome-mediated complete degradation of …
3,899 results