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Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.
Thuita JK, Wolf KK, Murilla GA, Bridges AS, Boykin DW, Mutuku JN, Liu Q, Jones SK, Gem CO, Ching S, Tidwell RR, Wang MZ, Paine MF, Brun R. Thuita JK, et al. Among authors: wang mz. PLoS Negl Trop Dis. 2015 Feb 5;9(2):e0003409. doi: 10.1371/journal.pntd.0003409. eCollection 2015 Feb. PLoS Negl Trop Dis. 2015. PMID: 25654243 Free PMC article.
CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE. Wang MZ, et al. Drug Metab Dispos. 2006 Dec;34(12):1985-94. doi: 10.1124/dmd.106.010587. Epub 2006 Sep 22. Drug Metab Dispos. 2006. PMID: 16997912 Free PMC article.
Novel arylimidamides for treatment of visceral leishmaniasis.
Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA. Wang MZ, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16. doi: 10.1128/AAC.00250-10. Epub 2010 Apr 5. Antimicrob Agents Chemother. 2010. PMID: 20368397 Free PMC article.
Diamidines for human African trypanosomiasis.
Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA, Thuita JK, Barrett MP, Tidwell RR. Paine MF, et al. Among authors: wang mz. Curr Opin Investig Drugs. 2010 Aug;11(8):876-83. Curr Opin Investig Drugs. 2010. PMID: 20721830 Review.
Development of novel drugs for human African trypanosomiasis.
Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP. Brun R, et al. Among authors: wang mz. Future Microbiol. 2011 Jun;6(6):677-91. doi: 10.2217/fmb.11.44. Future Microbiol. 2011. PMID: 21707314 Free article. Review.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA. Zhu X, et al. Among authors: wang mz. Antimicrob Agents Chemother. 2012 Jul;56(7):3690-9. doi: 10.1128/AAC.06404-11. Epub 2012 Apr 16. Antimicrob Agents Chemother. 2012. PMID: 22508306 Free PMC article.
740 results