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A new antibiotic with potent activity targets MscL.
Iscla I, Wray R, Blount P, Larkins-Ford J, Conery AL, Ausubel FM, Ramu S, Kavanagh A, Huang JX, Blaskovich MA, Cooper MA, Obregon-Henao A, Orme I, Tjandra ES, Stroeher UH, Brown MH, Macardle C, van Holst N, Ling Tong C, Slattery AD, Gibson CT, Raston CL, Boulos RA. Iscla I, et al. Among authors: kavanagh a. J Antibiot (Tokyo). 2015 Jul;68(7):453-62. doi: 10.1038/ja.2015.4. Epub 2015 Feb 4. J Antibiot (Tokyo). 2015. PMID: 25649856 Free PMC article.
Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites.
Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA. Jarrad AM, et al. Among authors: kavanagh am. Eur J Med Chem. 2015 Aug 28;101:96-102. doi: 10.1016/j.ejmech.2015.06.019. Epub 2015 Jun 18. Eur J Med Chem. 2015. PMID: 26117821 Free PMC article.
Mucin Binding Reduces Colistin Antimicrobial Activity.
Huang JX, Blaskovich MA, Pelingon R, Ramu S, Kavanagh A, Elliott AG, Butler MS, Montgomery AB, Cooper MA. Huang JX, et al. Among authors: kavanagh a. Antimicrob Agents Chemother. 2015 Oct;59(10):5925-31. doi: 10.1128/AAC.00808-15. Epub 2015 Jul 13. Antimicrob Agents Chemother. 2015. PMID: 26169405 Free PMC article.
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
Gallardo-Godoy A, Muldoon C, Becker B, Elliott AG, Lash LH, Huang JX, Butler MS, Pelingon R, Kavanagh AM, Ramu S, Phetsang W, Blaskovich MA, Cooper MA. Gallardo-Godoy A, et al. Among authors: kavanagh am. J Med Chem. 2016 Feb 11;59(3):1068-77. doi: 10.1021/acs.jmedchem.5b01593. Epub 2016 Jan 27. J Med Chem. 2016. PMID: 26734854 Free PMC article.
368 results