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2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF, Andersen UB, Holst JJ, Hansen HS. Hansen KB, et al. Among authors: hansen hs. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. doi: 10.1210/jc.2011-0647. Epub 2011 Jul 21. J Clin Endocrinol Metab. 2011. PMID: 21778222
GPR119 as a fat sensor.
Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Hansen HS, et al. Trends Pharmacol Sci. 2012 Jul;33(7):374-81. doi: 10.1016/j.tips.2012.03.014. Epub 2012 May 2. Trends Pharmacol Sci. 2012. PMID: 22560300 Review.
Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats.
Hankir MK, Seyfried F, Hintschich CA, Diep TA, Kleberg K, Kranz M, Deuther-Conrad W, Tellez LA, Rullmann M, Patt M, Teichert J, Hesse S, Sabri O, Brust P, Hansen HS, de Araujo IE, Krügel U, Fenske WK. Hankir MK, et al. Among authors: hansen hs. Cell Metab. 2017 Feb 7;25(2):335-344. doi: 10.1016/j.cmet.2016.12.006. Epub 2017 Jan 5. Cell Metab. 2017. PMID: 28065827 Free article.
Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes.
Mandøe MJ, Hansen KB, Windeløv JA, Knop FK, Rehfeld JF, Rosenkilde MM, Holst JJ, Hansen HS. Mandøe MJ, et al. Among authors: hansen kb, hansen hs. Nutr Diabetes. 2018 Jan 12;8(1):2. doi: 10.1038/s41387-017-0011-z. Nutr Diabetes. 2018. PMID: 29330461 Free PMC article. Clinical Trial.
432 results