Smutny T - Search Results

1

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).

Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P. Carazo Fernández A, et al. Among authors: smutny t. Toxicol Lett. 2015 Mar 4;233(2):68-77. doi: 10.1016/j.toxlet.2015.01.013. Epub 2015 Jan 24. Toxicol Lett. 2015. PMID: 25625231

2

2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

Smutny T, Nova A, Drechslerová M, Carazo A, Hyrsova L, Hrušková ZR, Kuneš J, Pour M, Špulák M, Pavek P. Smutny T, et al. J Med Chem. 2016 May 26;59(10):4601-10. doi: 10.1021/acs.jmedchem.5b01891. Epub 2016 May 12. J Med Chem. 2016. PMID: 27145071

3

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.

Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P. Hyrsova L, et al. Among authors: smutny t. Toxicol Lett. 2019 Jan;300:81-91. doi: 10.1016/j.toxlet.2018.10.028. Epub 2018 Oct 27. Toxicol Lett. 2019. PMID: 30394306

4

Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.

Dusek J, Skoda J, Holas O, Horvatova A, Smutny T, Linhartova L, Hirsova P, Kucera O, Micuda S, Braeuning A, Pavek P. Dusek J, et al. Among authors: smutny t. Toxicol Lett. 2019 Oct 1;313:1-10. doi: 10.1016/j.toxlet.2019.05.024. Epub 2019 Jun 4. Toxicol Lett. 2019. PMID: 31170421

5

Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.

Smutny T, Bernhauerova V, Smutna L, Tebbens JD, Pavek P. Smutny T, et al. Arch Toxicol. 2022 Jan;96(1):195-210. doi: 10.1007/s00204-021-03177-y. Epub 2021 Oct 23. Arch Toxicol. 2022. PMID: 34689256

6

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.

Skoda J, Dusek J, Drastik M, Stefela A, Dohnalova K, Chalupsky K, Smutny T, Micuda S, Gerbal-Chaloin S, Pavek P. Skoda J, et al. Among authors: smutny t. Cells. 2020 Nov 24;9(12):2532. doi: 10.3390/cells9122532. Cells. 2020. PMID: 33255185 Free PMC article.

7

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier.

Pavek P, Smutny T. Pavek P, et al. Among authors: smutny t. Drug Metab Rev. 2014 Feb;46(1):19-32. doi: 10.3109/03602532.2013.835819. Epub 2013 Sep 10. Drug Metab Rev. 2014. PMID: 24020384 Review.

8

Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.

Smutny T, Mani S, Pavek P. Smutny T, et al. Curr Drug Metab. 2013 Dec;14(10):1059-69. doi: 10.2174/1389200214666131211153307. Curr Drug Metab. 2013. PMID: 24329114 Free PMC article. Review.

9

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P. Rulcova A, et al. Among authors: smutny t. Pharmacol Rep. 2013;65(5):1322-35. doi: 10.1016/s1734-1140(13)71491-9. Pharmacol Rep. 2013. PMID: 24399729 Free article.

10

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P. Smutny T, et al. Arch Toxicol. 2014 Dec;88(12):2243-59. doi: 10.1007/s00204-014-1254-2. Epub 2014 May 14. Arch Toxicol. 2014. PMID: 24819614

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

31 results

Search Page

Filters