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Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.
Frame IJ, Deniskin R, Rinderspacher A, Katz F, Deng SX, Moir RD, Adjalley SH, Coburn-Flynn O, Fidock DA, Willis IM, Landry DW, Akabas MH. Frame IJ, et al. Among authors: akabas mh. ACS Chem Biol. 2015 Mar 20;10(3):775-83. doi: 10.1021/cb500981y. Epub 2015 Jan 30. ACS Chem Biol. 2015. PMID: 25602169 Free PMC article.
Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation.
Sosa Y, Deniskin R, Frame IJ, Steiginga MS, Bandyopadhyay D, Graybill TL, Kallal LA, Ouellette MT, Pope AJ, Widdowson KL, Young RJ, Akabas MH. Sosa Y, et al. Among authors: akabas mh. ACS Infect Dis. 2019 Oct 11;5(10):1738-1753. doi: 10.1021/acsinfecdis.9b00168. Epub 2019 Aug 14. ACS Infect Dis. 2019. PMID: 31373203 Free PMC article.
UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.
Brunner R, Ng CL, Aissaoui H, Akabas MH, Boss C, Brun R, Callaghan PS, Corminboeuf O, Fidock DA, Frame IJ, Heidmann B, Le Bihan A, Jenö P, Mattheis C, Moes S, Müller IB, Paguio M, Roepe PD, Siegrist R, Voss T, Welford RW, Wittlin S, Binkert C. Brunner R, et al. Among authors: akabas mh. J Biol Chem. 2013 Aug 2;288(31):22576-83. doi: 10.1074/jbc.M113.453159. Epub 2013 Jun 10. J Biol Chem. 2013. PMID: 23754276 Free PMC article.
Taking Charge: Feeding Malaria via Anion Channels.
Ekland EH, Akabas MH, Fidock DA. Ekland EH, et al. Among authors: akabas mh. Cell. 2011 May 27;145(5):645-7. doi: 10.1016/j.cell.2011.05.012. Cell. 2011. PMID: 21620131 Free article.
98 results