Keratins regulate β-cell mitochondrial morphology, motility, and homeostasis.
Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam CM, Toivola DM.
Silvander JSG, et al.
FASEB J. 2017 Oct;31(10):4578-4587. doi: 10.1096/fj.201700095R. Epub 2017 Jun 30.
FASEB J. 2017.
PMID: 28666985
K8(-/-) beta-cell mitochondria have decreased levels of total and mitochondrial cytochrome c, which correlates with a reduction in electron transport complexes I and IV. This provokes loss of mitochondrial membrane potential and reduction of ATP and insulin amount, as seen …
K8(-/-) beta-cell mitochondria have decreased levels of total and mitochondrial cytochrome c, which correlates with a reduction in el …