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PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.
Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M. Vasheghani F, et al. Among authors: lagares d. Ann Rheum Dis. 2015 Mar;74(3):569-78. doi: 10.1136/annrheumdis-2014-205743. Epub 2015 Jan 8. Ann Rheum Dis. 2015. PMID: 25573665 Free PMC article.
Fibrosis--a lethal component of systemic sclerosis.
Ho YY, Lagares D, Tager AM, Kapoor M. Ho YY, et al. Among authors: lagares d. Nat Rev Rheumatol. 2014 Jul;10(7):390-402. doi: 10.1038/nrrheum.2014.53. Epub 2014 Apr 22. Nat Rev Rheumatol. 2014. PMID: 24752182 Review.
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. Lagares D, et al. Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23. Nat Med. 2017. PMID: 29058717 Free PMC article.
Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. Lagares D, et al. Nat Med. 2017 Dec 7;23(12):1499. doi: 10.1038/nm1217-1499b. Nat Med. 2017. PMID: 29216045
47 results