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4,119 results

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Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
Hett EC, Xu H, Geoghegan KF, Gopalsamy A, Kyne RE Jr, Menard CA, Narayanan A, Parikh MD, Liu S, Roberts L, Robinson RP, Tones MA, Jones LH. Hett EC, et al. Among authors: roberts l. ACS Chem Biol. 2015 Apr 17;10(4):1094-8. doi: 10.1021/cb5009475. Epub 2015 Jan 29. ACS Chem Biol. 2015. PMID: 25571984
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.
Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB. Li J, et al. Among authors: roberts l. ACS Chem Biol. 2017 Dec 15;12(12):2970-2974. doi: 10.1021/acschembio.7b00683. Epub 2017 Nov 13. ACS Chem Biol. 2017. PMID: 29088528
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.
Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, Hulce JJ, Wei B, Whiteley LO, Hayward MM, Cravatt BF. Lanning BR, et al. Nat Chem Biol. 2014 Sep;10(9):760-767. doi: 10.1038/nchembio.1582. Epub 2014 Jul 13. Nat Chem Biol. 2014. PMID: 25038787 Free PMC article.
Detection of cell-cell interactions via photocatalytic cell tagging.
Oslund RC, Reyes-Robles T, White CH, Tomlinson JH, Crotty KA, Bowman EP, Chang D, Peterson VM, Li L, Frutos S, Vila-Perelló M, Vlerick D, Cromie K, Perlman DH, Ingale S, Hara SDO, Roberts LR, Piizzi G, Hett EC, Hazuda DJ, Fadeyi OO. Oslund RC, et al. Among authors: roberts lr. Nat Chem Biol. 2022 Aug;18(8):850-858. doi: 10.1038/s41589-022-01044-0. Epub 2022 Jun 2. Nat Chem Biol. 2022. PMID: 35654846
Click-enabled heterotrifunctional template for sequential bioconjugations.
Beal DM, Albrow VE, Burslem G, Hitchen L, Fernandes C, Lapthorn C, Roberts LR, Selby MD, Jones LH. Beal DM, et al. Among authors: roberts lr. Org Biomol Chem. 2012 Jan 21;10(3):548-54. doi: 10.1039/c1ob06398g. Epub 2011 Nov 21. Org Biomol Chem. 2012. PMID: 22101938
Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium.
Porter JD, Watson J, Roberts LR, Gill SK, Groves H, Dhariwal J, Almond MH, Wong E, Walton RP, Jones LH, Tregoning J, Kilty I, Johnston SL, Edwards MR. Porter JD, et al. Among authors: roberts lr. J Antimicrob Chemother. 2016 Oct;71(10):2767-81. doi: 10.1093/jac/dkw222. Epub 2016 Jul 25. J Antimicrob Chemother. 2016. PMID: 27494903 Free PMC article.
The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Part 2.
Wakenhut F, Tran TD, Pickford C, Shaw S, Westby M, Smith-Burchnell C, Watson L, Paradowski M, Milbank J, Stonehouse D, Cheung K, Wybrow R, Daverio F, Crook S, Statham K, Leese D, Stead D, Adam F, Hay D, Roberts LR, Chiva JY, Nichols C, Blakemore DC, Goetz GH, Che Y, Gardner I, Dayal S, Pike A, Webster R, Pryde DC. Wakenhut F, et al. Among authors: roberts lr. ChemMedChem. 2014 Jul;9(7):1387-96. doi: 10.1002/cmdc.201400046. Epub 2014 Apr 11. ChemMedChem. 2014. PMID: 24729518
Determination of Antibody-Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation.
Bessire AJ, Ballard TE, Charati M, Cohen J, Green M, Lam MH, Loganzo F, Nolting B, Pierce B, Puthenveetil S, Roberts L, Schildknegt K, Subramanyam C. Bessire AJ, et al. Among authors: roberts l. Bioconjug Chem. 2016 Jul 20;27(7):1645-54. doi: 10.1021/acs.bioconjchem.6b00192. Epub 2016 Jun 13. Bioconjug Chem. 2016. PMID: 27206324
4,119 results