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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Fang S, et al. Among authors: downes m. Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5. Nat Med. 2015. PMID: 25559344 Free PMC article.
Unique forms of human and mouse nuclear receptor corepressor SMRT.
Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM. Ordentlich P, et al. Among authors: downes m. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2639-44. doi: 10.1073/pnas.96.6.2639. Proc Natl Acad Sci U S A. 1999. PMID: 10077563 Free PMC article.
Humanized xenobiotic response in mice expressing nuclear receptor SXR.
Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RM. Xie W, et al. Among authors: downes m. Nature. 2000 Jul 27;406(6794):435-9. doi: 10.1038/35019116. Nature. 2000. PMID: 10935643
Identification of a nuclear domain with deacetylase activity.
Downes M, Ordentlich P, Kao HY, Alvarez JG, Evans RM. Downes M, et al. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10330-5. doi: 10.1073/pnas.97.19.10330. Proc Natl Acad Sci U S A. 2000. PMID: 10984530 Free PMC article.
Corepressors and nuclear hormone receptor function.
Ordentlich P, Downes M, Evans RM. Ordentlich P, et al. Among authors: downes m. Curr Top Microbiol Immunol. 2001;254:101-16. doi: 10.1007/978-3-662-10595-5_5. Curr Top Microbiol Immunol. 2001. PMID: 11190569 Review. No abstract available.
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. Downes M, et al. Mol Cell. 2003 Apr;11(4):1079-92. doi: 10.1016/s1097-2765(03)00104-7. Mol Cell. 2003. PMID: 12718892 Free PMC article.
521 results