Dooley C - Search Results

1

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.

Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, Yongye AB, Houghten RA, Yu Y. Hu M, et al. Among authors: dooley c. Eur J Med Chem. 2015 Mar 6;92:270-81. doi: 10.1016/j.ejmech.2014.12.049. Epub 2014 Dec 29. Eur J Med Chem. 2015. PMID: 25559207

2

Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.

Li Y, Cazares M, Wu J, Houghten RA, Toll L, Dooley C. Li Y, et al. Among authors: dooley c. J Med Chem. 2016 Feb 11;59(3):1239-45. doi: 10.1021/acs.jmedchem.5b01899. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26789491

3

De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library.

Houghten RA, Dooley CT, Appel JR. Houghten RA, et al. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1947-51. doi: 10.1016/j.bmcl.2004.01.090. Bioorg Med Chem Lett. 2004. PMID: 15050634

4

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Bioorg Med Chem. 2009 Aug 1;17(15):5583-97. doi: 10.1016/j.bmc.2009.06.026. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19576786 Free PMC article.

5

Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.

Li Y, Dooley CT, Misler JA, Debevec G, Giulianotti MA, Cazares ME, Maida L, Houghten RA. Li Y, et al. ACS Comb Sci. 2012 Dec 10;14(12):673-9. doi: 10.1021/co300110t. Epub 2012 Nov 8. ACS Comb Sci. 2012. PMID: 23110623 Free PMC article.

6

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Eans SO, et al. J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4. J Med Chem. 2015. PMID: 25996309

7

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.

McLaughlin JP, Rayala R, Bunnell AJ, Tantak MP, Eans SO, Nefzi K, Ganno ML, Dooley CT, Nefzi A. McLaughlin JP, et al. Int J Mol Sci. 2022 Aug 25;23(17):9623. doi: 10.3390/ijms23179623. Int J Mol Sci. 2022. PMID: 36077029 Free PMC article.

8

Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.

Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. Nefzi A, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4331-8. doi: 10.1016/j.bmcl.2006.05.053. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750366

9

Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.

Martínez-Mayorga K, Medina-Franco JL, Giulianotti MA, Pinilla C, Dooley CT, Appel JR, Houghten RA. Martínez-Mayorga K, et al. Among authors: dooley ct. Bioorg Med Chem. 2008 Jun 1;16(11):5932-8. doi: 10.1016/j.bmc.2008.04.061. Epub 2008 Apr 27. Bioorg Med Chem. 2008. PMID: 18468907 Free PMC article.

10

Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.

Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Reilley KJ, et al. AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27. AAPS J. 2010. PMID: 20422341 Free PMC article.

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