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TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?
Blaney Davidson EN, van Caam AP, Vitters EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent PL, van de Loo FA, van der Kraan PM. Blaney Davidson EN, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van caam ap, van den berg wb. Osteoarthritis Cartilage. 2015 Mar;23(3):478-86. doi: 10.1016/j.joca.2014.12.005. Epub 2014 Dec 18. Osteoarthritis Cartilage. 2015. PMID: 25529198 Free article.
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging.
de Hooge AS, van de Loo FA, Bennink MB, Arntz OJ, de Hooge P, van den Berg WB. de Hooge AS, et al. Among authors: van de loo fa, van den berg wb. Osteoarthritis Cartilage. 2005 Jan;13(1):66-73. doi: 10.1016/j.joca.2004.09.011. Osteoarthritis Cartilage. 2005. PMID: 15639639 Free article.
Osteophytes: relevance and biology.
van der Kraan PM, van den Berg WB. van der Kraan PM, et al. Among authors: van den berg wb. Osteoarthritis Cartilage. 2007 Mar;15(3):237-44. doi: 10.1016/j.joca.2006.11.006. Epub 2007 Jan 3. Osteoarthritis Cartilage. 2007. PMID: 17204437 Free article. Review.
Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling.
Blaney Davidson EN, Vitters EL, van Lent PL, van de Loo FA, van den Berg WB, van der Kraan PM. Blaney Davidson EN, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van den berg wb. Arthritis Res Ther. 2007;9(5):R102. doi: 10.1186/ar2305. Arthritis Res Ther. 2007. PMID: 17922907 Free PMC article.
596 results