Dunn BM - Search Results

1

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.

Goldfarb NE, Ohanessian M, Biswas S, McGee TD Jr, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM. Goldfarb NE, et al. Among authors: dunn bm. Biochemistry. 2015 Jan 20;54(2):422-33. doi: 10.1021/bi501088e. Epub 2015 Jan 7. Biochemistry. 2015. PMID: 25513833 Free PMC article.

2

Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.

Clemente JC, Moose RE, Hemrajani R, Whitford LR, Govindasamy L, Reutzel R, McKenna R, Agbandje-McKenna M, Goodenow MM, Dunn BM. Clemente JC, et al. Among authors: dunn bm. Biochemistry. 2004 Sep 28;43(38):12141-51. doi: 10.1021/bi049459m. Biochemistry. 2004. PMID: 15379553

3

Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.

Liu Z, Huang X, Hu L, Pham L, Poole KM, Tang Y, Mahon BP, Tang W, Li K, Goldfarb NE, Dunn BM, McKenna R, Fanucci GE. Liu Z, et al. Among authors: dunn bm. J Biol Chem. 2016 Oct 21;291(43):22741-22756. doi: 10.1074/jbc.M116.747568. Epub 2016 Aug 30. J Biol Chem. 2016. PMID: 27576689 Free PMC article.

4

Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).

Naffin-Olivos JL, Daab A, White A, Goldfarb NE, Milne AC, Liu D, Baikovitz J, Dunn BM, Rengarajan J, Petsko GA, Ringe D. Naffin-Olivos JL, et al. Among authors: dunn bm. Biochemistry. 2017 May 2;56(17):2304-2314. doi: 10.1021/acs.biochem.6b01066. Epub 2017 Apr 7. Biochemistry. 2017. PMID: 28346784 Free PMC article.

5

The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease.

Coman RM, Robbins AH, Fernandez MA, Gilliland CT, Sochet AA, Goodenow MM, McKenna R, Dunn BM. Coman RM, et al. Among authors: dunn bm. Biochemistry. 2008 Jan 15;47(2):731-43. doi: 10.1021/bi7018332. Epub 2007 Dec 20. Biochemistry. 2008. PMID: 18092815

6

Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.

Beyer BB, Johnson JV, Chung AY, Li T, Madabushi A, Agbandje-McKenna M, McKenna R, Dame JB, Dunn BM. Beyer BB, et al. Among authors: dunn bm. Biochemistry. 2005 Feb 15;44(6):1768-79. doi: 10.1021/bi047886u. Biochemistry. 2005. PMID: 15697202

7

Electrostatic switches that mediate the pH-dependent conformational change of "short" recombinant human pseudocathepsin D.

Goldfarb NE, Lam MT, Bose AK, Patel AM, Duckworth AJ, Dunn BM. Goldfarb NE, et al. Among authors: dunn bm. Biochemistry. 2005 Dec 6;44(48):15725-33. doi: 10.1021/bi0511686. Biochemistry. 2005. PMID: 16313175 Free PMC article.

8

Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease.

Coman RM, Robbins A, Goodenow MM, McKenna R, Dunn BM. Coman RM, et al. Among authors: dunn bm. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):320-3. doi: 10.1107/S174430910701161X. Epub 2007 Mar 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17401206 Free PMC article.

9

Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.

Clemente JC, Robbins A, Graña P, Paleo MR, Correa JF, Villaverde MC, Sardina FJ, Govindasamy L, Agbandje-McKenna M, McKenna R, Dunn BM, Sussman F. Clemente JC, et al. Among authors: dunn bm. J Med Chem. 2008 Feb 28;51(4):852-60. doi: 10.1021/jm701170f. Epub 2008 Jan 24. J Med Chem. 2008. PMID: 18215016

10

High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance.

Coman RM, Robbins AH, Goodenow MM, Dunn BM, McKenna R. Coman RM, et al. Among authors: dunn bm. Acta Crystallogr D Biol Crystallogr. 2008 Jul;D64(Pt 7):754-63. doi: 10.1107/S090744490801278X. Epub 2008 Jun 18. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18566511

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