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Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
Keough DT, Hocková D, Janeba Z, Wang TH, Naesens L, Edstein MD, Chavchich M, Guddat LW. Keough DT, et al. Among authors: guddat lw. J Med Chem. 2015 Jan 22;58(2):827-46. doi: 10.1021/jm501416t. Epub 2014 Dec 24. J Med Chem. 2015. PMID: 25494538
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Česnek M, Hocková D, Holý A, Dračínský M, Baszczyňski O, Jersey Jd, Keough DT, Guddat LW. Česnek M, et al. Among authors: guddat lw. Bioorg Med Chem. 2012 Jan 15;20(2):1076-89. doi: 10.1016/j.bmc.2011.11.034. Epub 2011 Dec 1. Bioorg Med Chem. 2012. PMID: 22178188
196 results