Zanger UM - Search Results

1

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.

Klein M, Thomas M, Hofmann U, Seehofer D, Damm G, Zanger UM. Klein M, et al. Among authors: zanger um. Drug Metab Dispos. 2015 Feb;43(2):273-83. doi: 10.1124/dmd.114.060962. Epub 2014 Dec 5. Drug Metab Dispos. 2015. PMID: 25480923

2

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Lang T, Klein K, Fischer J, Nüssler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, Zanger UM. Lang T, et al. Among authors: zanger um. Pharmacogenetics. 2001 Jul;11(5):399-415. doi: 10.1097/00008571-200107000-00004. Pharmacogenetics. 2001. PMID: 11470993

3

Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry.

Hofmann U, Schwab M, Seefried S, Marx C, Zanger UM, Eichelbaum M, Mürdter TE. Hofmann U, et al. Among authors: zanger um. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):371-80. doi: 10.1016/s1570-0232(03)00251-4. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12798197

4

Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine.

Tegude H, Schnabel A, Zanger UM, Klein K, Eichelbaum M, Burk O. Tegude H, et al. Among authors: zanger um. Drug Metab Dispos. 2007 Jun;35(6):946-54. doi: 10.1124/dmd.106.013565. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344340

5

A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.

Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, Zanger UM. Klein K, et al. Among authors: zanger um. Drug Metab Dispos. 2007 Aug;35(8):1247-50. doi: 10.1124/dmd.107.015149. Epub 2007 Apr 25. Drug Metab Dispos. 2007. PMID: 17460029

6

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.

Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M; German 5-FU Toxicity Study Group. Schwab M, et al. Among authors: zanger um. J Clin Oncol. 2008 May 1;26(13):2131-8. doi: 10.1200/JCO.2006.10.4182. Epub 2008 Feb 25. J Clin Oncol. 2008. PMID: 18299612 Clinical Trial.

7

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes.

Turpeinen M, Hofmann U, Klein K, Mürdter T, Schwab M, Zanger UM. Turpeinen M, et al. Among authors: zanger um. Drug Metab Dispos. 2009 May;37(5):1017-24. doi: 10.1124/dmd.108.025700. Epub 2009 Feb 9. Drug Metab Dispos. 2009. PMID: 19204080

8

UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo.

Riedmaier S, Klein K, Hofmann U, Keskitalo JE, Neuvonen PJ, Schwab M, Niemi M, Zanger UM. Riedmaier S, et al. Among authors: zanger um. Clin Pharmacol Ther. 2010 Jan;87(1):65-73. doi: 10.1038/clpt.2009.181. Epub 2009 Sep 30. Clin Pharmacol Ther. 2010. PMID: 19794410

9

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes.

Feidt DM, Klein K, Hofmann U, Riedmaier S, Knobeloch D, Thasler WE, Weiss TS, Schwab M, Zanger UM. Feidt DM, et al. Among authors: zanger um. Drug Metab Dispos. 2010 Sep;38(9):1589-97. doi: 10.1124/dmd.110.033886. Epub 2010 Jun 15. Drug Metab Dispos. 2010. PMID: 20551241

10

Inferring statin-induced gene regulatory relationships in primary human hepatocytes.

Schröder A, Wollnik J, Wrzodek C, Dräger A, Bonin M, Burk O, Thomas M, Thasler WE, Zanger UM, Zell A. Schröder A, et al. Among authors: zanger um. Bioinformatics. 2011 Sep 15;27(18):2473-7. doi: 10.1093/bioinformatics/btr416. Epub 2011 Jul 14. Bioinformatics. 2011. PMID: 21757465

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