Franklin DA - Search Results

1

MDM2-p53 pathway in hepatocellular carcinoma.

Meng X, Franklin DA, Dong J, Zhang Y. Meng X, et al. Among authors: franklin da. Cancer Res. 2014 Dec 15;74(24):7161-7. doi: 10.1158/0008-5472.CAN-14-1446. Epub 2014 Dec 4. Cancer Res. 2014. PMID: 25477334 Free PMC article. Review.

2

Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex.

Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA, Abadi AH. Rezk MS, et al. Chem Pharm Bull (Tokyo). 2016;64(1):34-41. doi: 10.1248/cpb.c15-00608. Chem Pharm Bull (Tokyo). 2016. PMID: 26726742 Free article.

3

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.

Franklin DA, He Y, Leslie PL, Tikunov AP, Fenger N, Macdonald JM, Zhang Y. Franklin DA, et al. Sci Rep. 2016 Nov 30;6:38067. doi: 10.1038/srep38067. Sci Rep. 2016. PMID: 27901115 Free PMC article.

4

The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.

Deisenroth C, Franklin DA, Zhang Y. Deisenroth C, et al. Among authors: franklin da. Cold Spring Harb Perspect Med. 2016 Dec 1;6(12):a026138. doi: 10.1101/cshperspect.a026138. Cold Spring Harb Perspect Med. 2016. PMID: 27908926 Free PMC article. Review.

5

Protection against High-Fat-Diet-Induced Obesity in MDM2^C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure.

Liu S, Kim TH, Franklin DA, Zhang Y. Liu S, et al. Among authors: franklin da. Cell Rep. 2017 Jan 24;18(4):1005-1018. doi: 10.1016/j.celrep.2016.12.086. Cell Rep. 2017. PMID: 28122227 Free PMC article.

6

p53 upregulates PLCε-IP3-Ca²⁺ pathway and inhibits autophagy through its target gene Rap2B.

Di J, Tang J, Qian H, Franklin DA, Deisenroth C, Itahana Y, Zheng J, Zhang Y. Di J, et al. Among authors: franklin da. Oncotarget. 2017 May 23;8(39):64657-64669. doi: 10.18632/oncotarget.18112. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029384 Free PMC article.

7

p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.

Leslie PL, Franklin DA, Liu Y, Zhang Y. Leslie PL, et al. Among authors: franklin da. Cell Rep. 2018 Aug 7;24(6):1484-1495. doi: 10.1016/j.celrep.2018.07.010. Cell Rep. 2018. PMID: 30089260 Free PMC article.

8

Nutrient availability dictates the regulation of metabolism by the ribosomal protein-MDM2-p53 pathway.

Franklin D, Zhang Y. Franklin D, et al. Mol Cell Oncol. 2017 Apr 3;5(3):e1302904. doi: 10.1080/23723556.2017.1302904. eCollection 2018. Mol Cell Oncol. 2017. PMID: 30250882 Free PMC article.

9

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway.

Franklin DA, Liu S, Jin A, Cui P, Guo Z, Arend KC, Moorman NJ, He S, Wang GG, Wan YY, Zhang Y. Franklin DA, et al. J Biol Chem. 2023 Jan;299(1):102739. doi: 10.1016/j.jbc.2022.102739. Epub 2022 Nov 23. J Biol Chem. 2023. PMID: 36435197 Free PMC article.

10

Carnitine o-octanoyltransferase is a p53 target that promotes oxidative metabolism and cell survival following nutrient starvation.

Sanford JD, Franklin D, Grois GA, Jin A, Zhang Y. Sanford JD, et al. J Biol Chem. 2023 Jul;299(7):104908. doi: 10.1016/j.jbc.2023.104908. Epub 2023 Jun 10. J Biol Chem. 2023. PMID: 37307919 Free PMC article.

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