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A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity.
Moine E, Denevault-Sabourin C, Debierre-Grockiego F, Silpa L, Gorgette O, Barale JC, Jacquiet P, Brossier F, Gueiffier A, Dimier-Poisson I, Enguehard-Gueiffier C. Moine E, et al. Among authors: brossier f. Eur J Med Chem. 2015 Jan 7;89:386-400. doi: 10.1016/j.ejmech.2014.10.057. Epub 2014 Oct 22. Eur J Med Chem. 2015. PMID: 25462254
Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.
Saïdani N, Botté CY, Deligny M, Bonneau AL, Reader J, Lasselin R, Merer G, Niepceron A, Brossier F, Cintrat JC, Rousseau B, Birkholtz LM, Cesbron-Delauw MF, Dubremetz JF, Mercier C, Vial H, Lopez R, Maréchal E. Saïdani N, et al. Among authors: brossier f. Antimicrob Agents Chemother. 2014 May;58(5):2586-97. doi: 10.1128/AAC.01445-13. Epub 2014 Feb 18. Antimicrob Agents Chemother. 2014. PMID: 24550329 Free PMC article.
Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella.
Bussière FI, Brossier F, Le Vern Y, Niepceron A, Silvestre A, de Sablet T, Lacroix-Lamandé S, Laurent F. Bussière FI, et al. Among authors: brossier f. PLoS One. 2015 Feb 17;10(2):e0116509. doi: 10.1371/journal.pone.0116509. eCollection 2015. PLoS One. 2015. PMID: 25689363 Free PMC article.
94 results