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Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A. Deluigi M, et al. Among authors: egloff p. Sci Adv. 2021 Jan 27;7(5):eabe5504. doi: 10.1126/sciadv.abe5504. Print 2021 Jan. Sci Adv. 2021. PMID: 33571132 Free PMC article.
Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A. Deluigi M, et al. Among authors: egloff p. Nat Commun. 2022 Jan 19;13(1):382. doi: 10.1038/s41467-021-27911-3. Nat Commun. 2022. PMID: 35046410 Free PMC article.
Biotinylation of Membrane Proteins for Binder Selections.
Kuhn BT, Zimmermann I, Egloff P, Hürlimann LM, Hutter CAJ, Miscenic C, Dawson RJP, Seeger MA, Geertsma ER. Kuhn BT, et al. Among authors: egloff p. Methods Mol Biol. 2020;2127:151-165. doi: 10.1007/978-1-0716-0373-4_11. Methods Mol Biol. 2020. PMID: 32112321 Free article.
The extracellular gate shapes the energy profile of an ABC exporter.
Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, Kucher S, Štefanić S, Karttunen M, Schäfer LV, Bordignon E, Seeger MA. Hutter CAJ, et al. Among authors: egloff p. Nat Commun. 2019 May 21;10(1):2260. doi: 10.1038/s41467-019-09892-6. Nat Commun. 2019. PMID: 31113958 Free PMC article.
Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Walter JD, Scherer M, Hutter CAJ, Garaeva AA, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Hürlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, van Geest G, Bruggmann R, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA. Walter JD, et al. Among authors: egloff p. EMBO Rep. 2022 Apr 5;23(4):e54199. doi: 10.15252/embr.202154199. Epub 2022 Mar 7. EMBO Rep. 2022. PMID: 35253970 Free PMC article.
32 results