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The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Mannion NM, Greenwood SM, Young R, Cox S, Brindle J, Read D, Nellåker C, Vesely C, Ponting CP, McLaughlin PJ, Jantsch MF, Dorin J, Adams IR, Scadden AD, Ohman M, Keegan LP, O'Connell MA. Mannion NM, et al. Among authors: scadden ad. Cell Rep. 2014 Nov 20;9(4):1482-94. doi: 10.1016/j.celrep.2014.10.041. Epub 2014 Nov 13. Cell Rep. 2014. PMID: 25456137 Free PMC article.
RNAi is antagonized by A-->I hyper-editing.
Scadden AD, Smith CW. Scadden AD, et al. EMBO Rep. 2001 Dec;2(12):1107-11. doi: 10.1093/embo-reports/kve244. Epub 2001 Nov 21. EMBO Rep. 2001. PMID: 11743024 Free PMC article.
Specific cleavage of hyper-edited dsRNAs.
Scadden AD, Smith CW. Scadden AD, et al. EMBO J. 2001 Aug 1;20(15):4243-52. doi: 10.1093/emboj/20.15.4243. EMBO J. 2001. PMID: 11483527 Free PMC article.
13 results