Clark K - Search Results

1

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.

Gazzard L, Appleton B, Chapman K, Chen H, Clark K, Drobnick J, Goodacre S, Halladay J, Lyssikatos J, Schmidt S, Sideris S, Wiesmann C, Williams K, Wu P, Yen I, Malek S. Gazzard L, et al. Among authors: clark k. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5704-5709. doi: 10.1016/j.bmcl.2014.10.063. Epub 2014 Oct 27. Bioorg Med Chem Lett. 2014. PMID: 25453805

2

Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.

Jackson DY, Quan C, Artis DR, Rawson T, Blackburn B, Struble M, Fitzgerald G, Chan K, Mullins S, Burnier JP, Fairbrother WJ, Clark K, Berisini M, Chui H, Renz M, Jones S, Fong S. Jackson DY, et al. Among authors: clark k. J Med Chem. 1997 Oct 10;40(21):3359-68. doi: 10.1021/jm970175s. J Med Chem. 1997. PMID: 9341911

3

Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.

Dubree NJ, Artis DR, Castanedo G, Marsters J, Sutherlin D, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Lowman HB, Skelton NJ, Jackson DY. Dubree NJ, et al. Among authors: clark k. J Med Chem. 2002 Aug 1;45(16):3451-7. doi: 10.1021/jm020033k. J Med Chem. 2002. PMID: 12139455

4

Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.

Castanedo GM, Sailes FC, Dubree NJ, Nicholas JB, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Marsters JC Jr, Jackson DY, Sutherlin DP. Castanedo GM, et al. Among authors: clark k. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2913-7. doi: 10.1016/s0960-894x(02)00597-8. Bioorg Med Chem Lett. 2002. PMID: 12270174

5

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR. Burdick DJ, et al. Among authors: clark k. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8. doi: 10.1016/s0960-894x(03)00084-2. Bioorg Med Chem Lett. 2003. PMID: 12643901

6

Structure-activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors.

Ockey DA, Dotson JL, Struble ME, Stults JT, Bourell JH, Clark KR, Gadek TR. Ockey DA, et al. Bioorg Med Chem. 2004 Jan 2;12(1):37-44. doi: 10.1016/j.bmc.2003.10.053. Bioorg Med Chem. 2004. PMID: 14697768

7

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR. Burdick DJ, et al. Among authors: clark k. Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9. doi: 10.1016/j.bmcl.2004.02.046. Bioorg Med Chem Lett. 2004. PMID: 15080978

8

CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads.

Castanedo G, Clark K, Wang S, Tsui V, Wong M, Nicholas J, Wickramasinghe D, Marsters JC Jr, Sutherlin D. Castanedo G, et al. Among authors: clark k. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1716-20. doi: 10.1016/j.bmcl.2005.12.004. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16384702

9

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.

Liu Y, Beresini MH, Johnson A, Mintzer R, Shah K, Clark K, Schmidt S, Lewis C, Liimatta M, Elliott LO, Gustafson A, Heise CE. Liu Y, et al. Among authors: clark k. J Biomol Screen. 2012 Feb;17(2):225-36. doi: 10.1177/1087057111421525. Epub 2011 Sep 22. J Biomol Screen. 2012. PMID: 21940710

10

Small-Molecule Library Subset Screening as an Aid for Accelerating Lead Identification.

Beresini MH, Liu Y, Dawes TD, Clark KR, Orren L, Schmidt S, Turincio R, Jones SW, Rodriguez RA, Thana P, Hascall D, Gross DP, Skelton NJ. Beresini MH, et al. J Biomol Screen. 2014 Jun;19(5):758-70. doi: 10.1177/1087057114522515. Epub 2014 Feb 11. J Biomol Screen. 2014. PMID: 24518067

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