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Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ, Ferrell R, Wu T, Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB, Harvey SA, Wang J, Starzl TE. Gandhi CR, et al. Among authors: kumar s. Gastroenterology. 2015 Feb;148(2):379-391.e4. doi: 10.1053/j.gastro.2014.10.008. Epub 2014 Oct 13. Gastroenterology. 2015. PMID: 25448926 Free PMC article.
Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.
Kumar S, Rani R, Karns R, Gandhi CR. Kumar S, et al. FASEB J. 2019 Mar;33(3):3825-3840. doi: 10.1096/fj.201802015R. Epub 2018 Dec 12. FASEB J. 2019. PMID: 30540918 Free PMC article.
We conclude that ALR deficiency-mediated oxidative stress induces generation of miR-540, which promotes steatosis by dysregulating peroxisomal and mitochondrial lipid homeostasis.-Kumar, S., Rani, R., Karns, R., Gandhi, C. R. Augmenter of liver regeneration protein …
We conclude that ALR deficiency-mediated oxidative stress induces generation of miR-540, which promotes steatosis by dysregulating peroxisom …
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